Inflammation promotes endothelial dysfunction, but the underlying mechanisms remain poorly defined in vivo. Using translational vascular function testing myocardial infarction patients, a situation where inflammation is prevalent, and knock-out (KO) mouse models we demonstrate role for mitogen-activated-protein-kinases (MAPKs) dysfunction. Myocardial significantly lowers mitogen stress kinase 1...

Abstract Background Epidural fibrosis is one of the aetiologies pain following a spinal revision surgery. It reported that specific members mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain. However, roles epidural caused by repeated surgeries and pain-related proteins in causing post surgery syndrome remain unknown. Using rat adhesion model, this study, we evalua...

Background/Aims MicroRNAs (miRNAs) play critical regulatory roles in the pathogenesis of pulmonary fibrosis. The aim this study was to explore whether miRNA antagomirs could serve as potential therapeutic agents interstitial lung diseases. Methods A mouse model fibrosis established by intratracheal injection bleomycin (BLM). Using microarray analysis, up-regulated miRNAs were identified during ...

Introduction: Increased oxidative stress is widely accepted to be a factor in the development and progression of Alzheimer’s disease. Triazine derivatives possess a wide range of pharmacological activities including anti-oxidative and anti-in.ammatory actions. In this study, we aimed to investigate the possible protective effect of 3-thioethyl-5,6-dimethoxyphenyl-1,2,4-triazine (TEDMT) on H2O2-...

Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes i...

Mitogen-activated protein kinase (MAPK) is an important component of the signal transduction pathway, which plays roles in regulating plant growth and development, abiotic stress. Potato (Solanum tuberosum L.) one most popular tuber crops world. Genome-wide identification analysis MAPK MAPKK gene family potato not clear. A total 20 genes 8 were identified genome. conservative motif showed that ...

Considering that MAPK (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signal...

This study aims to explore the material basis and mechanism of Baoyuan decoction in treatment chronic heart failure by network pharmacology molecular docking technology. There are 144 effective active ingredients 253 targets decoction. The key mainly include flavonoids such as quercetin, naringenin glazin. 240 intersecting between Baoyuantang failure, its core jun proto-oncogene, signal transdu...