نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

2015
Ilona Hromadnikova Katerina Kotlabova Lucie Hympanova Ladislav Krofta Kandiah Jeyaseelan

AIMS To demonstrate that pregnancy-related complications are associated with alterations in cardiovascular and cerebrovascular microRNA expression. Gene expression of 32 microRNAs (miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-33a-5p, miR-92a-3p, miR-100-5p, miR-103a-3p, miR-122-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR...

2017
Kaoru Toyama Naoki Kiyosawa Kenji Watanabe Hitoshi Ishizuka

Emerging evidence demonstrates functional contributions of microRNAs (miRNAs) to μ-opioid receptor (MOR) signaling, but the information so far has been mostly limited to their intracellular regulatory mechanisms. The present study aimed to investigate changes in plasma miRNA profiles elicited by opioid treatment in blood samples collected from clinical studies. Healthy male subjects were orally...

2017
Hyojin Kim Jeong Mi Yang Yan Jin Sanghoon Jheon Kwhanmien Kim Choon Taek Lee Jin-Haeng Chung Jin Ho Paik

Lung adenocarcinoma has distinctive clinicopathological features that are related to specific genetic alterations, including EGFR and KRAS mutations and ALK rearrangement. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate many important biological processes and influence cancer phenotypes. This study retrospectively investigated microRNA expression profiles, and their cli...

2016
Luigina Micolucci Most Mauluda Akhtar Fabiola Olivieri Maria Rita Rippo Antonio Domenico Procopio

BACKGROUND Asbestos is a harmful and exceptionally persistent natural material. Malignant mesothelioma (MM), an asbestos-related disease, is an insidious, lethal cancer that is poorly responsive to current treatments. Minimally invasive, specific, and sensitive biomarkers providing early and effective diagnosis in high-risk patients are urgently needed. MicroRNAs (miRNAs, miRs) are endogenous, ...

2017
Sachio Ito Yoshihiro Kamoto Akiko Sakai Kaori Sasai Tatsuro Hayashi Shinichi Toyooka Hiroshi Katayama

The incidence of lung adenocarcinoma has been increasing recently in smokers. The molecular target therapy has been developed for lung adenocarcinoma patients harboring EGFR gene mutation. However, the treatment modalities for patients without mutation are currently limited. Thus, analysis of EGFR gene mutation status at early stage is important strategy to classify the patients for improving t...

2016
Zhenyu Zhong Mengxin Lv Junxia Chen

Circular RNAs (circRNAs), a kind of non-coding RNAs, have shown large capabilities in gene regulation. However, the mechanisms underlying circRNAs remain largely unknown so far. Recent studies demonstrated that circRNAs play miRNA sponge effects and regulate gene expression by microRNA response elements. Here, we screened circRNA expression profiles of bladder carcinoma using microarray assay. ...

2017
Zhe Su Chaodong Zhou Ge Hong

Colorectal cancer (CRC) is the second leading cause of cancer-related death in the western country. MiR-103a is an important post-transcriptional regulator, which has been validated as a tumor suppressor in many human cancers. However, the detailed role of miR-103a in CRC remains to be elucidated. In our study, real-time RT-PCR was performed to detect the expression levels of miR-103a in CRC ce...

2017
Francesca Rosignolo Marialuisa Sponziello Laura Giacomelli Diego Russo Valeria Pecce Marco Biffoni Rocco Bellantone Celestino Pio Lombardi Livia Lamartina Giorgio Grani Cosimo Durante Sebastiano Filetti Antonella Verrienti

Context Trends toward more conservative management of papillary thyroid cancer (PTC) diminish the primacy of serum thyroglobulin (Tg) assays as a posttreatment surveillance tool. Objective To identify thyroid tumor-associated microRNAs (miRNAs) in the serum with potential for development as unique biomarkers of PTC recurrence. Methods We measured expression of 754 miRNAs in serum samples co...

Journal: :Cardiology journal 2016
Lingzhi Huang Lezhi Li Xiaofang Chen Huiling Zhang Zeya Shi

BACKGROUND Acute myocardial infarction (AMI) is commonly known as the heart attack. The molecular events involved in the development of AMI remain unclear. This study was to investigate the expression of miR-103a in patients with high blood pressure (HBP) and AMI patients with and without HBP, as well as its effect on endothelial cell functions. METHODS MiR-103a expression in plasma and perip...

Journal: :Comparative Biochemistry and Physiology B 2021

Nicotinic acetylcholine receptors (nAChRs) are a class of ligand-gated ion channels that participate in signal transduction and reported to play an important role the immunomodulation vertebrates invertebrates. Previous studies have shown nAChRs mollusks undergone large-scale expansion after tandem repeats retrotransposition, with most observed bivalves. This study characterized sequence repeat...

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