intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. in this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with lidocaine following perineal operation. forty patients were randomly allocated to two groups: 20 patients in the control group received 2 ml of 5% heav...

BACKGROUND Midazolam may suppress conditioned fear after an aversive event by disrupting the memory trace formed during conditioning, by altering the emotional part of the aversive event, or by the combination of both effects. The purpose of the present study was to determine whether affective-related processes contribute to the amnesic-like effects of midazolam on aversive events. METHODS Th...

BACKGROUND Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Midazolam is used in patients with pathologic effects of oxidative stresses such as infection, hemodynamic instability and hypoxia. We investigated whether midazolam protects the Central Nervous System (CNS) from soman intoxication. The present study w...

Here, we examined how repetition under midazolam, a benzodiazepine that prevents the storage of novel associations, affects cued-recall performance of paired-associates. We contrasted word pairs that were initially studied and tested repeatedly without any successful recall prior to the midazolam injection, with other pairs that were studied for the first time after the injection of midazolam. ...

Our study sought to determine whether premedication with intramuscular midazolam would decrease the time to induction of anaesthesia with intravenous midazolam, and if so whether induction of anaesthesia would be as rapid as with thiopentone or ketamine, intravenously. Eight-nine patients, ASA physical status I or II, received midazolam 0.2 mg X kg-1, thiopentone 3.0 mg X kg-1, or ketamine 2.0 ...

OBJECTIVES To compare the efficacy of oral midazolam alone with a combination of oral midazolam and ketamine in children requiring laceration repair. DESIGN A randomised, double-blind, placebo-controlled study. SETTING Paediatric emergency department. PARTICIPANTS Children 1-10 years of age with lacerations requiring sedation. INTERVENTIONS Using a computer-generated sequence, children ...

BACKGROUND Reports from Thailand suggest that a growing number of people who inject drugs (IDU) are now injecting midazolam, a legal benzodiazepine with potent amnestic and ventilatory depressant effects. We therefore sought to examine midazolam injection among a community-recruited sample of Thai IDU. METHODS We examined the prevalence and correlates of midazolam injection among 252 IDU part...

AIM To compare the acceptability and efficacy of orally administered commercially available midazolam syrup and injection midazolam mixed in honey for performing venepuncture. MATERIALS AND METHODS This double blind randomized controlled trial enrolled 40 anxious and healthy 2 to 6 years olds. All subjects received either syrup midazolam or injection midazolam mixed in honey (0.5 mg/kg) per o...

long-term exposure to opiates induces physical dependence and tolerance. the main goal of this study was to evaluate the effects of dextromethorphan and midazolam and their combination on morphine tolerance and dependence in mice. different groups of mice were rendered randomly and received morphine (50 mg/kg, sc), morphine (50 mg/kg, sc) + dextromethorphan (25,50 or 75 mg/kg, ip), morphine (50...

objective: to compare the effect of intrathecal midazolam versus neostigmine added to lidocaine on the duration of sensory block and the duration of postoperative pain relief in women undergoing colporaphy in spinal anesthesia. materials and methods: in this double blind clinical trial we evaluated 60women (asa) i,ii that were candidate to elective colporaphy. the patients were randomly divided...