Article history: Received on: 28/11/2012 Revised on: 17/12/2012 Accepted on: 24/12/2012 Available online: 29/12/2012 The effects of different anti-estrogenic chemicals were evaluated in guppy, Poecilia reticulata on sex differentiation and survival. New-born fry of the fish were fed diets containing genistein (1 gm kg), tamoxifen (100 mg kg), methanol extract of Basella alba (1 gm kg) and 17α-m...

A new technique to measure the uro-genital parameters such as the lengths of urovaginal septum, corpora cavernosa and anogenital distance on the sagittal sections of the pelvic region of female fetus of rat under microscope equipped with a micrometer was developed. In the examination of 180 normal female fetuses on the 21st day of gestation, relationships were observed between the fetal body we...

pregnancy prevention raises much concern to many pet owners. female cats usually show undesirable behaviour during oestrus. nowadays, researchers try to explore the reliable and effective ways to prevent oestrus signs in queens. the results of their studies prove that hormone therapy is probably one of the most reliable methods for this purpose. the aim of our study was to compare the effect of...

To understand the sex reversal characteristics in the longtooth grouper (Epinephelus bruneus), this study examined the sex reversal and artificial masculinization of wild caught E. bruneus reared in indoor rearing tank after a 17α-methyltestosterone injection. To domesticate a broodstock, 64 wild caught E. bruneus, between 47.0 to 110.0 cm in total length and from 1.5 to 21.4 kg in body weight,...

We report a 62-yr-old man with severe jaundice and weight loss attributed to methyltestosterone administration. This case is unusual both in the severity of the cholestasis as well as the associated findings that mimicked an underlying malignancy.

Various man-made agents like pesticides, industrial chemicals and some natural substances have the potential to alter hormonal pathways that regulate reproductive processes in certain species of wildlife. Until now, only a few investigations have been undertaken to determine the effects of these substances on reproductive capacities (fecundity and fertility) in exposed invertebrate aquatic spec...

A multidimensional study on the glucuronidation of anabolic androgenic steroids and their phase I metabolites by 11 recombinant human UDP-glucuronosyltransferases (UGTs) was carried out using liquid chromatographic-tandem mass spectrometric analyses. Large differences between the enzymes with respect to the conjugation profiles of the 11 tested aglycones were detected. Two UGTs, 1A6 and 1A7, di...