More than one third of all proteins are metalloproteins. They catalyze important reactions such as photosynthesis, nitrogen fixation and CO2 reduction. Metalloproteins such as the olfactory receptors also serve as highly elaborate sensors. Here we review recent developments in functional metalloprotein design using the genetic code expansion approach. We show that, through the site-specific inc...

The design of artificial miniature lanthanide proteins, provide an opportunity to access new functional metalloproteins as well insight into native biochemistry.

Metal ions play pivotal roles in protein structure, function and stability. The functional and structural diversity of proteins in nature expanded with the incorporation of metal ions or clusters in proteins. Approximately one-third of these proteins in the databases contain metal ions. Many biological and chemical processes in nature involve metal ion-binding proteins, aka metalloproteins. Man...

Metalloproteins are an important class of proteins and perform a variety of biological processes. They are ideally suited for Synchrotron Radiation studies. In particular, X-ray region of the spectrum has been very effectively exploited not only for crystallographic structure determinations but X-ray absorption fine structure (XAFS) and more recently X-ray solution scattering techniques have al...

1.1 Metalloproteins as mediators of life processes Revealing detailed molecular mechanisms associated with metalloproteins is highly desired for the advancement of both basic and clinical research. Metalloproteins represent one of the most diverse classes of proteins, containing intrinsic metal ions which provide catalytic, regulatory, or structural roles critical to protein function. The metal...