In the age of the world-wide web global media data—often called media assets—, stored in multimedia database management systems (MM-DBMS), will increasingly be made accessible to virtually everyone. Hence, lots of heterogeneous clients with different, not safely predictable capabilities of storing, processing, and presenting media data are willing to access these MM-DBMSs (which may be part of ...

The culture media optimization is an inevitable part of upstream process development in therapeutic monoclonal antibodies (mAbs) production. The quality by design (QbD) approach defines the assured quality of the final product through the development stage. An important step in QbD is determination of the main quality attributes. During the media optimization, some of the main quality attribute...

We present the problem of tracing rays in 2D and 3D heterogeneous isotropic media as a set of optimization problems. Each optimization problem is obtained by applying Fermat’s principle to an approximation of the travel time equation from a fixed source to a fixed receiver. We assume a piecewise linear ray path that simplifies the computations of the problem, in the same way Mao and Stuart sugg...

Since Mycoplasma hyopneumoniae isolation in appropriate media is a difficult task and impractical for daily routine diagnostics, Nested-PCR (N-PCR) techniques are currently used to improve the direct diagnostic sensitivity of Swine Enzootic Pneumonia. In a first experiment, this paper describes a N-PCR technique optimization based on three variables: different sampling sites, sample transport m...

Optimization of production medium is required to maximize the metabolite yield. This can be achieved by using a wide range of techniques from classical "one-factor-at-a-time" to modern statistical and mathematical techniques, viz. artificial neural network (ANN), genetic algorithm (GA) etc. Every technique comes with its own advantages and disadvantages, and despite drawbacks some techniques ar...

PURPOSE To introduce the concept of dose-mass-based inverse optimization for radiotherapy applications. MATERIALS AND METHODS Mathematical derivation of the dose-mass-based formalism is presented. This mathematical representation is compared to the most commonly used dose-volume-based formulation used in inverse optimization. A simple example on digitally created phantom is presented. The pha...

The selection and optimization of nutritional constituents as well as their levels for the improved production of antibiotic by Nonomuraea sp. JAJ18 were carried out using combination of both nonstatistical one-factor-at-a-time (OFAT) method and statistical response surface methodology (RSM). Using OFAT method, starch and (NH4)2SO4 were identified as suitable carbon and nitrogen sources, respec...