Effects of a combination of medetomidine-ketamine as a chemical restraint and antagonistic effects of atipamezole on this combination were investigated in 5 lions. The medetomidine (47.6-58.4 micrograms/kg) and ketamine (1.9-5.7 mg/kg) combination provided complete immobilization with good analgesia and muscle relaxation in 4 lions, while one lioness was poorly sedated by medetomidine, and addi...

Sedation in sea lions exhibiting abnormal neurologic signs may require modification of established sedatior protocols because of the likely interaction between effects of the sedative and physiologic changes in diseased animals The effects of two sedative combinations, 0.07 mg/kg medetomidine and 0.07 mg/kg medetomidine plus 0.2 mg/kg butorphanol, were compared between California sea lions (Zal...

Efficacy of medetomidine HCl anesthesia was evaluated in 48 horses, divided randomly into six groups (n=8). Initially, propofol, ketamine and chloral hydrate were evaluated individually as sole anesthetic drugs in groups A C and E, respectively. Later on the efficacy of medetomidine HCl as pre-anesthetic was assessed by using it in combination with other drugs. In group B, medetomidine HCl was ...

Clinicophysiological, haematological and biochemical effects of xylazine (0.05mgkg(-1)) and medetomidine (0.01mgkg(-1)) were studied in nine adult goats after lumbosacral subarachnoid administration. The onset of analgesia by xylazine and medetomidine was observed in 9.11+/-1.07 and 8.66+/-2.37min (mean+/-S.E.), respectively. Both alpha(2)-agonists produced moderate analgesia of hind quarter, p...

The aim was to apply medetomidine sedation for electrophysiological measurements in mink (Neovison vison). Adult animals (N = 15) of standard type were used. Initially, sedation with an i.m. injection of medetomidine (Dorbene 0.20 ml, 200 micrograms) was used. However, sufficient sedation was not reached. The next step was to sedate with 0.8 ml of medetomidine (Dorbene 0.80 ml, 800 micrograms)....

OBJECTIVE To investigate heart rate characteristics in dogs undergoing ovariohysterectomy following premedication with medetomidine or acepromazine. DESIGN Clinical trial. ANIMALS 43 client-owned dogs. PROCEDURE 24-hour ambulatory electrocardiography was performed beginning approximately 1 hour prior to administration of premedications. Dogs were premedicated with medetomidine and butorph...

This study aimed to determine the anesthetic efficacy of intranasal medetomidine/ketamine and diazepam/ketamine combinations in New Zealand White rabbits. For this purpose, 12 adult rabbits weighing 2.3‐4.1 kg were used by randomly dividing animals into two groups six animals: Medetomidine ‐ Ketamine (MK) Diazepam (DK). Intranasally, medetomidine (0.2 mg kg‐1) ketamine (10 combination was admin...

This study aimed to investigate and compare the antagonistic effects of atipamezole, yohimbine and prazosin on medetomidine-induced diuresis in healthy cats. Five cats were repeatedly used in each of the 9 groups. One group was not medicated. Cats in the other groups received 40 µg/kg medetomidine intramuscularly and saline (as the control), 160 µg/kg prazosin, or 40, 160 or 480 µg/kg atipamezo...

OBJECTIVE To evaluate effects of medetomidine on anesthetic dose requirements, cardiorespiratory variables, plasma cortisol concentrations, and behavioral pain scores in dogs undergoing ovariohysterectomy. DESIGN Randomized, prospective study. ANIMALS 12 healthy Walker-type hound dogs. PROCEDURE Dogs received medetomidine (40 micrograms/kg [18.2 micrograms/lb] of body weight, i.m.; n = 6)...