Continuous optimization of business process execution including its adaptation to changes within the market environment or the company itself becomes increasingly important. Therefore, business performance related decision support needs to be an integral part of Business Process Management (BPM) Environments. We experienced that such a support is especially useful when dealing with complex and ...

BACKGROUND In open TCI and anaesthesia display systems, the choice of pharmacokinetic (PK) parameter sets of opioids is clinically relevant. Accuracy and bias of the PK models may be affected by administration mode and the co-administered hypnotic drug. We retrospectively evaluated the performance of eight PK parameter sets for alfentanil in two data sets (infusion and bolus application). MET...

BACKGROUND Kinetics of inhaled agents are often described by physiological models. However, many pharmacokinetic concepts, such as context-sensitive half-times, have been developed for drugs described by classical compartmental models. We derived classical compartmental models that describe the course of the alveolar concentrations (FA) generated by the physiological uptake and distribution mod...

The best approaches to minimizing resource scarcity, removing valuable waste streams, and re-establishing a circular economic chain of recycled thermoplastics are cascade them into product life cycles their valorization combined with sustainable raw materials. As one part this goal, WPC was formulated from three PE plastic wastes: linear low-density polyethylene (LLDPE), medium-density (MDPE), ...

Abstract. The ability to detect the existence of nonlinear dynamics may facilitate medical diagnostics for identifying, monitoring and predicting transitions from health to sickness. Detection of such transitions depends on the quality of the available biomedical signals and the relevance of the nonlinear statistics employed. The dangers of using irrelevant statistics are discussed. A simple in...

BACKGROUND The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase in the methods to provide and control sedation and analgesia for these patients. In this study, we evaluated different combinations of propofol and remifentanil, administered through a target-controlled infusion system, to estimate the optimal concentrati...