The present investigation was undertaken to evaluate the bronchodilating effect and bronchial hyperreactivity of alcoholic extract of Taxus baccata Linn. (AET) leaves in experimental animals. Bronchodilator activity of AET was studied on the histamine and acetylcholine aerosol induced bronchospasm in guinea pigs and bronchial hyperreactivity was studied on bronchoalveolar lavage fluid (BALF) in...

The present investigation was undertaken to evaluate the bronchodilating effect and bronchial hyperreactivity of alcoholic extract of Taxus baccata Linn. (AET) leaves in experimental animals. Bronchodilator activity of AET was studied on the histamine and acetylcholine aerosol induced bronchospasm in guinea pigs and bronchial hyperreactivity was studied on bronchoalveolar lavage fluid (BALF) in...

Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lip...

increased number of mast cells at the site of infection is widely regarded as important host defense against parasites. the kinetics of mucosal mast cells and connective tissue mast cells responses were studied in the intestines of 68 female cflp mice infected with 100 schistosoma mansoni cercariae. the number of mucosal mast cells and the connective tissue mast cells increased from week 3 and ...

BACKGROUND Anti-allergic drugs, such as tranilast and ketotifen, inhibit the release of chemokines from mast cells. However, we know little about their direct effects on the exocytotic process of mast cells. Since exocytosis in mast cells can be monitored electrophysiologically by changes in the whole-cell membrane capacitance (Cm), the absence of such changes by these drugs indicates their mas...

Novel polyherbal formulation (PHE) containing mainly the ethanolic extract of Adhatoda vasica Nees. (leaf), Clerodendrum serratum Linn. (root), Curcuma longa Linn. (rhizome), Solanum xanthocarpum Schrad & Wendl. (fruit) and Piper longum Linn. (fruit). HPTLC analysis of the herbal extracts of PHE revealed presence of 0.25%w/w vasicine, 3.4%w/w piperine, 1.56%w/w curcumin and 0.04%w/w solasodine....

There has long been evidence that inhibitors of chymotryptic proteinases can inhibit the degranulation of rodent mast cells, but their actions on human mast cells and the contribution of mast cell chymase itself have received little attention. We investigated the ability of the selective chymase inhibitor Z-Ile-Glu-Pro-Phe-CO(2)Me and other proteinase inhibitors to inhibit chymase and cathepsin...

Increasing pollution has elicited various airway complications of which the Allergic asthma is one. Manifestation of allergic asthma is always associated with anaphylaxis and mast cell degranulation. In the pursuit of new herbal drugs to prevent or treat allergic asthma, Lygodium flexuosum was studied for its anti-histaminic and mast cell stabilizing activity. In the present study rats were sen...

Aglaia roxburghiana is a traditional remedy for a variety of diseases. The ethanolic extract of the leaves was screened for related activities were upon it exhibited significant anti-inflammatory activity in rats in acute and chronic models. There was no acute toxicity in mice upto 2g/kg. The extract protected the mast cell deregulation by compound 48/80 and inhibited histamine induced contract...