Using the canine thalamic infarction model, we have investigated the effects of 10 ml/kg of 20% mannitol on the hemodynamics of the ischemic brain. Mannitol was found to cause an increase in rCBF, but it is not marked in animals with severe ischemic foci. Increases were statistically significant in the animals with moderate ischemia. Increases in rCBF due to mannitol administration lasted for a...

Purpose: To compare the efficacies of 3 % (w/v) hypertonic saline, 20 mannitol, and 10 mannitol plus (v/v) glycerol in management intracranial hypertension.Methods: Patients with pressure > mmHg received saline (HT cohort, n = 78) or w/v (MT 82) (MG 73) until was reduced below 15 mmHg. Neurologic outcomes, hemodynamic parameters, clinical biochemistry were evaluated as indices pathological p...

BACKGROUND Osmotherapy is the frequently used for the treatment of intracranial pressure. The purpose of the study was to compare the effect of equiosmolar solution of 3% hypertonic saline and 20% mannitol on brain relaxation in supratentorial tumor surgery. METHODS After institutional review board approval and written informed consent, 50 patients aged >18, Glasgow Coma Scale (GCS) >13 with ...

Intravenous mannitol may lead to electrolyte disturbances involving sodium and potassium and resulting in cardiac dysfunction. This report demonstrates that when mannitol is given during intracranial surgery it can cause large increase potassium ion concentration and decrease in sodium ion concentration in the absence of any other possible causes. Intraoperative checks of serum electrolyte leve...

1* Associate Professor, Dept of Neurosurgery, Mamata Medical College, Khammam, Telangana 2 Assistant Professor, Dept of Neurosurgery, Sidhartha Medical College, Vijayawada, Andhra Pradesh *Corresponding Author Jagadeesh Babu. K Associate Professor, Department of Neurosurgery, Mamata Medical College, Khammam, Telangana, Email: [email protected], Phone no: 8374590275 Abstract Medical mana...

Shigella organisms are divided biochemically into two main groups distinguished by their ability to ferment mannitol. Non-mannitol-fermenting strains of Sh. flexneri type 88 (biochemical type newcastle) and of Sh. flexneri type 103 (Mumford and Mohr, 1944) are, however, well recognized, and it is probable that similar variants occur among other mannitol-fermenting dysentery bacilli. The organis...

BACKGROUND The effects of mannitol administration on acute kidney injury (AKI) prevention remain uncertain, as the results from clinical studies were conflicting. Due to the lack of strong evidence, the KDIGO Guideline for AKI did not propose completely evidence-based recommendations on this issue. METHODS We searched PubMed, EMBASE, clinicaltrials.gov and Cochrane Controlled Trials Register....

Accepted, April 28, 2005. OBJECTIVE: Mannitol is the standard of care for patients with increased intracranial pressure (ICP), but multiple administrations of mannitol risk renal toxicity and fluid accumulation in the brain parenchyma with consequent worsening of cerebral edema. This preliminary study assessed the safety and efficacy of small-volume injections of 23.4% sodium chloride solution ...

A rat model of middle cerebral artery permanent occlusion was established using the modified Longa method. Successfully established model animals were treated by blood-letting puncture at twelve Jing-Well points of the hand, and/or by injecting mannitol into the caudal vein twice daily. Brain tissue was collected at 24, 48 and 72 hours after modeling, and blood was collected through the retinal...

The percentage dose of lactulose and mannitol excreted in urine after oral ingestion is used as a noninvasive method of assessing small intestinal permeability. The collection of incomplete or inaccurately timed urine samples can lead to errors in estimation of sugar probe molecules. We describe an HPLC method for the simultaneous determination of lactulose and mannitol in serum after oral inge...