The effectiveness of newer macrolides in acute Q fever for 113 patients was recorded. The mean times to defervescence were 2.9 days for doxycycline and 3.3, 3.9, 3.9, and 6.4 days for clarithromycin, roxithromycin, erythromycin, and beta-lactams, respectively (P < 0.01 for macrolides versus beta-lactams). We conclude that macrolides may be an adequate empirical antibiotic therapy for acute Q fe...

Cyanobacteria are rich sources of structurally-diverse molecules with promising pharmacological activities. Marine cyanobacteria have been proven to be true producers of some significant bioactive metabolites from marine invertebrates. Macrolides are a class of bioactive compounds isolated from marine organisms, including marine microorganisms in particular. The structural characteristics of ma...

A high prevalence of macrolide resistant isolates has been found among staphylococci isolated from animals (4). The erm(C) gene is the most common gene encoding macrolide resistance in staphylococci (8). It is well known that expression of the erm(C) gene is normally regulated by formation of hairpin structures upstream for the erm(C) gene (5,9) rendering the start codon of erm(C) gene non-acce...

results among the specimens, 11 cases (1.4%) were culture-positive. among these isolates, only two isolates had high mic values for erythromycin and clarithromycin. pulsed-field gel electrophoresis analysis of the isolates revealed 6 pfge profiles (a-f) among which three and two isolates had the same patterns in profiles a and b, respectively. conclusions azithromycin can be a good drug of choi...

The comparative effectiveness and safety of macrolides, quinolones and amoxicillin/clavulanate (A/C) for the treatment of patients with acute bacterial exacerbation of chronic bronchitis (ABECB) was evaluated in the present study. PubMed, Current Contents and the Cochrane Central Register of Controlled Trials were searched to identify relevant randomised controlled trials (RCTs). In total, 19 R...

II. Structure Elucidation on Polyketide Antibiotics by Biosynthetic Means A. Elasnin B. Herbimycin C. Irumamycin D. Phthoramycin E. Aurantinin F. Xanthoquinodin III. Biosynthesis and Stereochemistry of Macrolide Antibiotics and Production of New Hybrid Macrolides and Polyketide A. Biosynthesis of the Aglycone Moiety in 16-Membered Macrolides, Leucomycins and Tylosin B. The Intact Incorporation ...