AIM To evaluate the treatment of endometrial hyperplasia (EH) with different progestins. METHODS Eighty-two women with simple EH without atypia were included. Patients were offered oral progestagens and were randomized to one of three options for 3 months: medroxyprogesterone acetate (MPA, 10 mg/day), lynestrenol (LYN, 15 mg/day) and norethisterone (NET, 15 mg/day) for 10 days per cycle. Pati...

Shelesnyak (1959) first suggested that histamine might be the inducing factor for decidualization and that it might be involved in the process of implantation in the rat (Shelesnyak & Kraicer, 1964). Treatment with oestrogen results in histamine depletion from the rat uterus (Szego, 1966; McKercher, Van Orden, Bhatnagar & Burke, 1973), and it was suggested that histamine might be involved in th...

OBJECTIVES To examine, among young women, the association of individual hormonal contraceptives, within two broad groupings, with antidepressant therapy. METHODS In a nationwide register-based study, we examined the prescription rates of antidepressant drugs in relation to individual combined hormonal and progestin-only contraceptives among Swedish women aged 16-31 years (N = 917,993). Drug d...

Aim: To evaluate the treatment of endometrial hyperplasia (EH) with different progestins. Methods: Eighty-two women with simple EH without atypia were included. Patients were offered oral progestagens and were randomized to one of three options for 3 months: medroxyprogesterone acetate (MPA, 10 mg/day), lynestrenol (LYN, 15 mg/day) and norethisterone (NET, 15 mg/day) for 10 days per cycle. Pati...

We investigated whether changes in plasma oxidative properties could occur after oral (hormonal) contraceptive (OC) administration in female rats and whether such changes could be responsible for the platelet increase in aggregation and lipid biosynthesis observed with that treatment. Platelets and plasma (platelet-poor) from control and OC (ethinyl estradiol + lynestrenol)-treated rats were pr...

Recent papers have reported small clinical trials of progestins in combination with oestrogens in the treatment of advanced breast cancer (Landau et al., 1962 ; Stoll, 1965 ; Crowley and MacDonald, 1965). This form of combination therapy is based upon experimental observations in rats made by Huggins et al. (1962). The clinical reports to date suggest that a beneficial response may be expected ...

©FSRH J Fam Plann Reprod Health Care 2009: 35(4) Background Two studies recently published in the British Medical Journal, a retrospective cohort study using information from the Danish registries1 and the MEGA case-control study for which cases were identified via specialised anticoagulation clinics in The Netherlands,2 revisit the question of whether so-called ‘third generation’ combined oral...

Preliminary Comncain BRITISH96 hepatocellular damage was seen in all six cases biopsied, but cholestasis was seen in only two of them. In this respect our findings are in conformity with the biochemical observations of Eisalo and of Palva and Mustala, in that abnormal enzyme levels are seen more frequently than abnormal biliary excretion tests. According to Eisalo et al. the biochemical changes...

incarceration at the site of laparoscope insertion that resulted in intestinal obstruction, and claimed that this was the first report of this complication of laparoscopy. Both patients eventually needed small bowel resection, 14 and 21 days after laparoscopy. These two patients, and the one described above, were initially well after laparoscopy and then started to vomit on the third and the si...