Plasminogen deficiency is a rare disease characterized by ligneous conjunctivitis and infections. We observed a 3-year-old Italian boy presenting ligneous conjunctivitis and low plasma levels of plasminogen. Twenty-three different mutations on the PLG gene have been reported to date, but mutation analysis had been troublesome for the presence of highly homologous genes. The aim of the study was...

Ligneous conjunctivitis is a type of chronic characterized by the presence pseudomembranes on conjunctival surface. It can present as part multisystem disease with involvement other mucous membranes. A 1-year-old girl presented features conjunctivitis. Local examination revealed thick exudates in left tarsal conjunctiva, which was diagnosed an ulcer pseudomembrane and sterile culture. The patie...

purpose : to report an association of ligneous conjunctivitis (lc) and congenital hydrocephalus case report : the patient was a 3.5-year-old boy with a history of long standing conjunctivitis with copious ocular discharge and photophobia, waxing and waning for some time. he also had suffered from occlusive congenital hydrocephalus that required placement of a ventriculoperitoneal shunt. conjunc...

Herein, we elucidate that ligneous conjunctivitis (LC) was proved as an IgG4-related disease (IgG4-RD) by a series of pathologic studies from primary and recurrent episodes of an LC patient. LC was diagnosed based on clinical presentation and pathological appearance; furthermore, combined with serological examination and immunohistochemical study, the case also conformed to the diagnosis of IgG...

A middle-aged woman presented for evaluation of gingival swelling. She was previously diagnosed with hypoplasminogenemia and current plasminogen level was 29% (reference value: 78–130%). Intraoral examination revealed swelling of the right maxillary gingiva (Figure 1). Biopsy with routine histopathologic analysis revealed fibrinoid deposits and a mixed inflammatory infiltrate within the lamina ...

A considerable number of agents have been proposed as causing ligneous conjunctivitis. We report the first case to arise as a side effect of tranexamic acid (Cyclokapron), an anti-fibrinolytic drug used in the treatment of menorrhagia. In addition to the typical conjunctival changes our patient had lesions affecting the gingiva and the peritoneum the last causing considerable protein loss into ...