the most frequent adverse effects of indomethacin like other nsaids are gastro–intestinal and central nervous system disturbances. extended release or enteric release formulations minimize these symptoms. the objective of this study was to develop an extended release pellet formulation of indomethacin by the centrifugation (rotary fluid bed granulation) or powder layering method. layered, nonpa...

Extended layering of ionic liquids (ILs) on the mica surface has been reported by several groups previously and it is generally accepted that the electrostatic interaction at the IL/mica interface is critical to the observed extended layering. Here we report that, indeed, water adsorption on the mica surface is the key to the extended layering of ionic liquids. The atomic force microscopy (AFM)...

The formation of many nebkha dunes relies on the layering of clonal plants. The microenvironmental conditions of such phytogenic nebkha are heterogeneous depending on the aspect and slope. Exploring the effects of aspect on clonal reproduction and biomass allocation can be useful in understanding the ecological adaptation of species. We hypothesized that on the windward side layering propagatio...

The Resource Description Framework and the Resource Description Framework Schema Specification are supposed to be the foundations of the Semantic Web, in that all other Semantic Web languages are to be layered on top of them. It turns out that such a layering cannot be achieved in a straightforward way. This paper describes the problem with the straightforward layering and lays out several alte...

Abstract Double-diffusive systems, such as thermosolutal convection, in which the density depends on two components that diffuse at different rates, are prone to both steady and oscillatory instabilities. Such systems can evolve into layered states, components, also density, adopt a “staircase” profile. Turbulent transport is enhanced significantly state. Here we exploit an analogy between magn...

The layering principle has been long identified as a way to increase the interoperability and to improve the design of telecommunication protocols, where each layer offers services to adjacent upper layers and requires functionalities from adjacent lower ones. In the past, layering has enabled fast development of interoperable systems, but at the same time limited the performance of the overall...

We introduce a toy model of crumpled sheets, and use Monte Carlo simulation to show there is a first-order phase transition in the model, from a disordered dilute phase to a mixture with a layered phase. We demonstrate the transition through two order parameters, corr and lay, the first of which measures orientational order while the second measures bulk layering. An important feature of the ar...

The stack in various forms[1] has been widely used as an architectural template for networking systems. Recently the stack has been subject to criticism for a lack of flexibility. However, when it comes right down to it nobody has offered a truly compelling alternative. Various “cross-layer” optimizations have been proposed, but these optimizations are frequently hacks to achieve a particular g...

Iterative Layering is an existing pre-synthesis technique that can be used for constructing a near-optimal representation of the input circuit. Originally, the Iterative Layering algorithm uses SAT instances extensively. However, in the original implementation, they are solved either by exhaustive enumeration of all possible assignments of input variables, or by using BDDs. Both approaches perf...