Objective: A number of studies have demonstrated the potential antitumor effects of saffron and its constituents on different malignant cells in vitro. It has been reported that a novel glycoconjugate isolated from corms and callus of saffron possesses cytotoxic activity against different tumor cellswith nitric oxide (NO) production. These data suggest that the cytotoxic effect of saffron extra...

Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untre...

background: because of its effect on speech and swallowing, laryngeal squamous cell carcinoma is a devastating disease which has been shown to have a poor survival rate. abundant research is being carried out in search of novel biomarkers that can aid the process of diagnosis and treatment of this disease. fxyd3, a modulator of na/k-atpase, is presented as a biomarker in some cancers. fxyd3 exp...

introduction: cigarette smoking and alcohol consumption have a well-known effect on the development of upper aerodigestive tract carcinomas, but such a role for opium is questionable. this study was designed to assess the correlation between opium inhalation and cancer of the larynx and upper esophagus. materials and methods: fifty eight patients with laryngeal cancer, ninety eight patients wit...

To discover candidate biomarkers for diagnosis and detection of human laryngeal carcinoma and explore possible mechanisms of this cancer carcinogenesis, two-dimensional strong cation-exchange/reversed-phase nano-scale liquid chromatography/mass spectrometry analysis was used to identify differentially expressed proteins between the laryngeal carcinoma tissue and the adjacent normal tissue. As a...

 Background: Focal laryngeal candidiasis is not reported widely and is very infrequently recognized clinically. This disease is rare and may occur after pulmonary, pharyngeal and esophageal candidiasis or as part of disseminated disease. It is also secondary to inhaled steroid therapy which is usually mild and has been reported in 10-15 percent of patients taking these medications.  Case Pr...

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untre...

Head and neck cancer is the sixth most common cancer worldwide and laryngeal cancer represents the largest subgroup. However, the molecular mechanism underlying its malignant behavior and progression is not clarified. Accumulating evidence has shown that Notch1 signaling pathway plays a central role in carcinogenesis, but its potential role in regulating the development of laryngeal carcinoma, ...

squamous cell carcinoma comprises 95% of laryngeal carcinomas. it is usually detected by laryngoscopic evaluation. imaging plays an important role in the evaluation of submucosal extension and staging of this malignancy. supraglottic, glottic and sublottic regions are separately evaluated. in supraglottic region extension of the mass to preepilottic and paraglottic spaces and cartilges invasion...