نتایج جستجو برای: kuemmerle
تعداد نتایج: 35 فیلتر نتایج به سال:
Background Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare hereditary autoinflammatory disease characterized by fever as well severe systemic and organ inflammation. Successful treatment was achieved with the interleukin-1β inhibitor canakinumab (CAN) in pivotal phase 3 study, which 45% of patients reached clinical remission after 16 weeks (primary endpoint) 1 . CA...
Background: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory condition characterized by severe systemic and organ inflammation. In phase 3 pivotal trial ( CLUSTER study), TRAPS patients have been successfully treated with the interleukin-1β inhibitor canakinumab. 45% of reached clinical remission after 16 weeks (primary endpoint) 1 . Canakinumab has...
Background Psychiatric comorbidities can be a significant additional burden in chronic diseases. The most common inflammatory rheumatic disease children and adolescents is juvenile idiopathic arthritis (JIA). Data on mental illness with JIA are heterogeneous. Objectives To assess the frequency of depressive anxious symptoms patients compared to healthy peers. Methods were analysed from controls...
Objectives To evaluate 24-month effectiveness and tolerability/safety of tocilizumab (TCZ) versus tumour necrosis factor inhibitor (TNFi), analysing predictors JADAS remission minimal disease activity (MDA), comparing 1 st 2 nd line TCZ. Methods BIKER WA 29358 is a 5-year multi-centre prospective, observational cohort study including polyarticular juvenile idiopathic arthritis (JIA) patients in...
Background: Golimumab (GOL) is approved for treatment of polyarticular juvenile idiopathic arthritis (pJIA) in patients 2 years and older. Data on long-term safety GOL this indication are limited. Objectives: To assess efficacy pJIA patients. Methods: In ongoing non-interventional observational study, clinical characteristics, disease activity parameters were analysed using the German Biologics...
Background The cryopyrin-associated periodic fever syndromes (CAPS) are hereditary monogenic autoinflammatory diseases with severe systemic and organ inflammation due to increased production of Interleukin-1β (IL-1β). subcutaneously administered monoclonal antibody canakinumab (CAN) effectively inhibits IL-1β results in rapid remission CAPS symptoms clinical trials as well real-life. Objectives...
Background: In clinical trials as well in real-life, the IL-1ß inhibitor canakinumab leads to rapid remission of symptoms treatment CAPS, a monogenic autoinflammatory disease with severe systemic and organ inflammation. Objectives: The RELIANCE registry is designed explore long-term safety effectiveness under routine practice conditions pediatric (≥2 years) adult patients including Muckle-Wells...
Background Familial Mediterranean Fever (FMF) is a chronic disease characterized by recurrent attacks of fever as well serositis and bears the risk serious complications (e. g. amyloidosis). Treatment FMF according to EULAR aims control acute subclinical inflammation improve patient´s quality life 1 . Clinical data indicate that inhibition interleukin-1? with canakinumab (CAN) effective in cont...
Background Golimumab (GOL) is approved for treatment of polyarticular juvenile idiopathic arthritis (pJIA) in patients 2 years and older. Data on long-term safety GOL this indication are limited. Objectives To assess effectiveness pJIA patients. Methods In ongoing non-interventional observational study, clinical characteristics, disease activity parameters were analysed using the German Biologi...
A potential solution to reduce high acquisition costs for airborne lidar (light detection and ranging) data is to combine lidar transects and optical satellite imagery to characterize forest vertical structure. Although multiple regression is typically used for such modeling, it seldom fully captures the complex relationships between forest variables. In an effort to improve these relationships...
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