BACKGROUND Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. M...

Studies in newborn humans have demonstrated alteration in the lipid, phospholipid and cholesterol content when compared with age-matched control. Membrane bound (Na+ + K+)ATPase activity is found to be significantly increased in jaundiced neonates. Alteration in membrane permeability characteristics in jaundiced neonates causes severe microenvironmental changes in red blood cell profile.

Pathophysiology of jaundice Jaundice is defined as the yellowish discoloration of the skin, mucous membranes and conjunctival membranes caused by hyperbilirubinemia, which is an excess of bilirubin in the blood. Discoloration is most noticeable in the face and descends cephalocaudally; with clearance of the yellowish hue occurring in the opposite direction. Most adults are visibly jaundiced whe...

background: phototherapy is believed to be a safe method for the management of hyperbilirubinemia. however, there are some controversial issues regarding the genotoxic effects of phototherapy on dna. the aim of this study was to investigate morphologically both phototherapy-induced dna double-strand breaks (dsbs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. me...

The determination of the frequency HDFN found in jaundiced newborns Sudan was goal analysis. In Omdurman maternity inside a Sudanese hospital, 220 mothers and their babies who had jaundice altogether were received hospital-Sudan prospective cross-sectional hospital-based analysis carried out them. addition to ABO Rhesus blood group typing, indirect antiglobulin test (IAT) direct coomb's (DA...

AIMS AND OBJECTIVES To determine the most effective position jaundiced neonates should assume during phototherapy from appraised randomised controlled trials. BACKGROUND Many local hospitals still alternate positions of jaundiced neonates receiving phototherapy despite the safe infant sleeping protocol of placing them supine. DESIGN A systematic review was conducted. METHODS Databases tha...

The mechanism of acute gastric ulceration in rats with obstructive jaundice was investigated in terms of the changes in the gastric mucosal blood flow, and the effect of vagotomy on ulceration was examined. 188 Sprague-Dawley rats weighing about 250 g were prepared and divided into 4 groups as follows; control group (sham operation), jaundiced group (ligation of the bile duct), vagotomized grou...

Systemic tumour necrosis factor (TNF) is present in jaundiced mice. Two soluble TNF receptors, sTNFr-P55 and sTNFr-P75 are reported to play a part in the natural defence against TNF. This study investigated the properties of circulating TNF and sTNFr in jaundiced mice. The data show that TNF in these mice is biologically inactive and that an increase of both sTNFr is seen (p < 0.001). Surgical ...