Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...

The purpose of this presentation is 3 fold and includes the past, present, and future: L To review the concept of skin-associated lymphoid tissue (SALT) 2. To summarize the experimental work related to lymphocyte-keratinocyte reactions in vitro 3. To briefly outline interferon related therapeutic implications for dermatologists In the past few years, several review articles concerning the immun...

The immune system (immunoglobulins, cell mediated immunity, phagocytosis complement, lysosomes, interferon, metabolic function, hormones, metabolic and respiratory alkalosis) is the natural mechanism which defends against cancer. Trace elements zinc, selenium, molybdenum, and manganese augment this natural mechanism. Zinc is essential for normal development and maintenance of the thymus. Reduce...

BALB/c mice were immunized with uninduced K562 erythroleukemia cells and hybridomas were isolated after fusion of immune spleen cells to P3/NS1 murine myeloma cells. One selected hybrid, designated 101,30, secreted an antibody of subclass immunoglobulin G2a which was specific for hematopoietic cells. Analysis of 10L-30 binding by comple ment-mediated cytotoxicity, indirect immunofluorescence, s...

Normal lymphocytes from the peripheral circulation represent a heterogenous population of cells with different surface markers and different functions. Some of these lymphocytes contain cytoplasmic inclusions called parallel tubular arrays (PTA). which can only be identified with certainty under the electron microscope. It is not known whether this ultrastructurally defined lymphocyte constitut...

lnterleukin-2 (11-2) therapy may improve immune reconstitution and reduce the risk of leukemic relapse in the setting of minimal residual disease by augmenting cytotoxic effector mechanisms directed at residual malignant cells. In addition. 11-2 in vitro promotes the release of cytokines including y-interferon (‘y-IFN) and tumor necrosis factor (TNF). which also possess antileukemic activity an...

In this brief review we will discuss some re cent trends in work on regulatory mechanisms involved in the selective expression of differentiated markers in human B-ceIllines as weIl as the types of controls involved in the expression and function of Epstein-Barrvirus (EBV) associated markers in human cells. A problem of special interest in this connection is the relation of the expression of EB...

Neural Modulation of Immunity presents the proceedings of an international symposium held in Brussels in the fall of 1983. Fifteen papers, each followed by a record of the discussion by participants in the conference, address aspects of CNS control and input into the immune response. The opening chapter by Cohn on the essential elements of the immune response offers a philosophical overview of ...

Neural Modulation of Immunity presents the proceedings of an international symposium held in Brussels in the fall of 1983. Fifteen papers, each followed by a record of the discussion by participants in the conference, address aspects of CNS control and input into the immune response. The opening chapter by Cohn on the essential elements of the immune response offers a philosophical overview of ...

THE SUCCESS of clinical allogeneic organ transplantation has led to a shortage of human organ donors. A solution to this increasing problem is the use of donor organs from outside the human species; Since nonhuman primates are not available in sufficient numbers, are too expensive to breed and keep, and their use is limited by ethical concern, they are very unlikely candidates for xenotransplan...