introduction: we evaluated the incidence and clinical outcome of patients with hypertensive acute ischemic stroke (ais) admitted to a tertiary care center in central india. in addition, we examined the status of stroke biomarkers namely neuron-specific enolase (nse), glial specific protein (s-100ββ), and inter-α-trypsin inhibitor heavy chain 4(itih4) in the serum of patients suffering from ais ...

INTRODUCTION We evaluated the incidence and clinical outcome of patients with hypertensive acute ischemic stroke (AIS) admitted to a tertiary care center in Central India. In addition, we examined the status of stroke biomarkers namely neuron-specific enolase (NSE), glial specific protein (S-100ββ), and inter-α-trypsin inhibitor heavy chain 4(ITIH4) in the serum of patients suffering from AIS w...

The goal of this study was to explore the plasma proteome of myelodysplastic syndrome (MDS) patients with refractory anemia with excess blasts subtype 2 (RAEB-2) in comparison to healthy controls. 20 plasma samples were separated with 2D electrophoresis and statistically processed with Progenesis SameSpots software. 47 significantly differing (P < 0.05) spots were observed, and 27 different pro...

BACKGROUND Liver biopsy is currently the gold standard for assessing liver fibrosis, and no reliable noninvasive diagnostic approach is available. Therefore a suitable serologic biomarker of liver fibrosis is urgently needed. METHODS We used a proteomics method based on 2-dimensional gel electrophoresis to identify potential fibrosis biomarkers. Serum samples from patients with varying degree...

BACKGROUND Stroke is the third leading cause of death and disability worldwide accounting for 400-800 strokes per 100,000 individuals each year. PURPOSE In the present study, we compared risk factors, clinical outcome, and prognostic biomarkers NSE, S-100 ßß and ITIH4 levels in young and old acute ischemic stroke (AIS) patients. METHODS We compared the risk factors and clinical outcomes in ...

The family of calgranulins includes S100A8 (calgranulin A), S100A9 B), which can appear as a heterodimer known S100A8/A9 or calprotectin, and S100A12 C). These proteins are related to different inflammatory conditions, immune-mediated diseases, sepsis considered biomarkers potential interest. This study aims evaluate if A12 could change in pigs with diarrhea due E. coli compare the changes othe...

Please cite this article as: Tan, Z., Hu, Z., Cai, E.Y., Alev, C., Yang, T., Li, Z., Sung, J., El-Sayed, Y.Y., Shaw, G.M., Stevenson, D.K., Butte, A.J., Sheng, G., Sylvester, K.G., Cohen, H.J., Ling, X.B., Serological Targeted Analysis of an ITIH4 Peptide Isoform: A Preterm Birth Biomarker and Its Associated SNP Implications, Journal of Genetics and Genomics (2015), doi: 10.1016/j.jgg.2015.06.001.

Ribosomes prepared from murine lymphosarcoma cells were phosphorylated by a cyclic AMP-independent protein kinase designated H4P kinase. H4P kinase was isolated as an inactive enzyme which was activated by Mg2+-ATP and an endogenous converting enzyme. In the absence of preactivation by Mg2+-ATP and an endogenous converting enzyme, H4P kinase catalyzed phosphorylation of 80, 60, and 40 S ribosom...

1The authors thank A. L. Archibald, M. F. Rothschild, and the EC PiGMaP group for distribution of DNA from the PiGMaP reference families, and D. Nicholson, C. Haley, and G. J. Lee for provision of database services and linkage analyses. Published as paper no. 11935, Journal Series, Agric. Res. Div., Univ. of Nebraska, Lincoln 68583-0908. 2To whom correspondence should be addressed: phone: (402)...