Although intraocular tumors reside in an immune privileged site, some tumors are rejected nonetheless. For example, intraocular adenovirus-induced (Ad5E1; adenovirus type 5 early region 1) tumors are rejected in syngeneic C57BL/6 mice by one of two pathways. One pathway leads to extensive necrosis of innocent bystander cells and culminates in destruction of the eye, a condition called phthisis....

Immune privilege in the eye is considered essential in the protection against local sight-threatening inflammatory responses. However, the deviant immune responses in the eye may also provide an ideal opportunity to uncontrolled growth of viruses or tumors by inhibiting intraocular immunological attack. To establish to what extent immune privilege interferes with T cell-mediated antitumor immun...

AIMS Immunoglobulin G4 (IgG4)-related disease is known to have diverse clinical manifestations. We report a case of IgG4-related ophthalmic disease misdiagnosed as intraocular tumor. METHODS Case report. RESULTS A 41-year-old man was referred to our department with a diagnosis of intraocular tumor, presumably choroidal melanoma. Although MR imaging was compatible with choroidal melanoma, he...

PURPOSE Immune privilege of the eye protects the nonregenerative ocular tissues from innate and adaptive immune-mediated inflammation. In the case of intraocular tumors, immune privilege can be arrested to allow for immune-mediated rejection. Activation of innate immune cells can contribute to necrosis of the intraocular tumor and bystander ocular tissue. Identifying the cellular components of ...

Intraocular lacrimal gland tissue is an extremely rare choristoma. A newborn girl was seen with a fleshy, vascular tumor arising from the peripheral iris and the anterior chamber angle. The tumor was treated with topical steroids on suspicion of a juvenile xanthogranuloma; later, it grew slightly and a secondary glaucoma developed. Histopathological examination of the resected tumor showed lacr...

The eye is normally an immunosuppressive environment. This condition is better known as immune privilege and protects the eye from immune-mediated inflammation of tissues that cannot regenerate. However, immune privilege creates a dilemma for the eye when intraocular neoplasms arise. In some cases, immune privilege is suspended, resulting in the immune rejection of intraocular tumors. This stud...

Introduction Choroidal melanoma is the most common intraocular malignancy . Diffusion weighted MRI (DWI) and the derived apparent diffusion coefficient (ADC) map has proven to be useful in tumor identification and treatment response monitoring . However, DWI of intraocular tumor, such as choroidal melanoma, has not been reported to date. The objective of the present study is to quantify ADC of ...