Background & Objective: Interleukin (IL)-10 is an important anti-inflammatory and immunomodulatory cytokine. Some authors believe that single nucleotide polymorphisms (SNP) in the promoter region of the IL-10 gene have been associated with susceptibility to HIV infection and progression to AIDS, but its role is not clearly defined yet. The present study was undertaken to evaluate the a...

conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at...

background: pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (rm). objective: to investigate the association between rm and five polymorphisms of cytokine genes, interleukin 10 (il-10), (-592 a/c, -819 c/t, -1082 a/g), il-6 (-174 c/g) and il-17 (-197 g/a) in iranian women. method: po...

objectives this study evaluates the correlation between hbv infection and snp in il-10 gene promoter. patients and methods ninety-six hbv-infected patients (32 chronic hepatitis b infection patients, 34 healthy carriers, 30 spontaneously recovered cases) and 31 healthy controls were enrolled. three biallelic (-819,-592,-1082) regions in the il-10 gene promoter were sequenced for all patients. r...

Background: The anti-inflammatory cytokine, interleukin 10 (IL 10), has a crucial role in periodontal diseases. gene coding for this cytokine is pleomorphic. In the promoter region of IL gene, two single nucleotide polymorphisms (SNPs), IL10 1082 and 819, have been discovered to affect expressions. Objective: To investigate association (IL-10-1082 G/A IL-10-819 C/T) with CPO. Patients Methods: ...

background uterine leiomyoma (uls) is the most common gynecological tumor and a significant health concern for many women .the interleukin-1 receptor antagonist (il-1ra) is a naturally occurring cytokine inhibiting interleukin- 1 (il-1) activity by binding to the il-1 receptors without signal transduction. objectives the aim of this study was to investigate the association between interleukin-1...

henoch–schönlein purpura (hsp), a common allergic hemorrhagic disease, occurs frequently in children affecting kidney, joint and skin. while interleukin-8 (il-8) plays an important role in inflammation, the association between il-8 gene +781 c/t polymorphism and hsp remains unclear. interleukin-8, an important chemokine related to the initiation and amplification of acute inflammatory responses...