Introduction: In the current study, protective effect of natural honey applied during ischemia/reperfusion (I/R) was studied on infarct size in ischemic heartheart. Methods: Ischemic hearthearts (n=8 per group) were mounted on a Langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. In control group, the hearts were perfused by ...

objective(s) this study aimed to examine whether acetyl-l-carnitine (alc) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then perfused by a modified krebs-henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched kreb...

background: the role of nitric oxide (no) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.    objective: to investigate the role of no of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, l-name, a non selective no synthase inhibit...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...

introduction: inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. the aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ace) inhibitor, ramiprilat and angiotensin type 1 (at1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat model...

Introduction: It has been reported that traumas such as transverse abdominal incision before myocardial ischemia result in a significantly decreased infarct size. This phenomenon is named remote preconditioning of trauma. Since small skin burn is one of most common traumas, the effect of this injury on ischemia-induced arrhythmias and infarct size was investigated in a rat model of ischemia-...

Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.  Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...

Objective(s): Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. Materials and Methods: Eighty male Wistar rats (250–300 g) were divided into 8 groups...

Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...