Polioviruses belong to Enterovirus C species and cause severe lesions of the nervous system. In post-polio eradication era, World Health Organisation recommends inactivated polio vaccines for effective long-term protection population. order meet needs global health, it is planned increase use traditional optimised introduce new types that are being developed based on current understanding RNA-c...

Virus inactivation by a number of protein denaturants commonly used in gel affinity chromatography for protein elution and gel recycling has been investigated. The enveloped viruses Sindbis, herpes simplex-1 and vaccinia, and the non-enveloped virus polio-1 were effectively inactivated by 0.5 M sodium hydroxide, 6 M guanidinium thiocyanate, 8 M urea and 70% ethanol. However, pH 2.6, 3 M sodium ...

Since 1992, surveillance for acute flaccid paralysis (AFP) cases was introduced in Malaysia along with the establishment of the National Poliovirus Laboratory at the Institute for Medical Research. In 2008, the Ministry of Health, Malaysia, approved a vaccine policy change from oral polio vaccine to inactivated polio vaccine (IPV). Eight states started using IPV in the Expanded Immunization Pro...

Studies with polio-infected HeLa cells using cell disruption techniques during the early stages of infection have shown that: The inoculum of poliovirus adsorbed on HeLa cells is largely inactivated. Infective virus accumulates in a monolayer sheet of cells in advance of release into the medium. The eclipse period is shorter in multiply infected cells than in those infected with a single particle.

Enclosed for your consideration for publication in BMC Pediatrics is the original manuscript, “An open-label randomized clinical trial in children of prophylactic paracetamol co-administered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b vaccine.”

OBJECTIVE To analyze the costs of vaccination regimens for introducing inactivated polio vaccine in routine immunization in Brazil. METHODS A cost analysis was conducted for vaccines in five vaccination regimens, including inactivated polio vaccine, compared with the oral polio vaccine-only regimen. The costs of the vaccines were estimated for routine use and for the "National Immunization Days...

Latar Belakang : Vaksin merupakan suspensi mikroorganisme yang dilemahkan atau dimatikan, protein antikgenik dari berbagai organisme tadi diberikan untuk mencegah, meringankan, mengobati penyakit-penyakit menular. pertama kali tercatat pada tahun 1769, dipublikasikan oleh Edward Jenner, yaitu specimen berasal lesi lengan seseorang terinfeksi Cowpox. Human Diploid Cells (HDC) salah satu sel digu...