introduction: a large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in parkinson's disease (pd). flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in e...

UNILATERAL injection of 6-hydroxydopamine (6-OH-DA) into the dopamine (DA) cell bodies in the substantia nigra of a rat induces a degeneration of the entire nigro-striatal DA neuron system (Ungerstedt, 1968, 1971a). The lesion causes the animal to deviate in movements and posture towards the lesioned side (Ungerstedt, 1968, 1971b). Due to the high specificity of the 6-OH-DA induced lesion (Unge...

Introduction: A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson's disease (PD). Flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in e...

introduction: animal models of parkinson’s disease (pd) with partial damage of nigrostriatal dopaminergic system are very suitable for development of treatment strategies. although drug-induced rotational behavior has been conventionally used for analysis of lesioned animals, but bcause of the development of sensitization, it is necessary to invent a pure behavioral test that can evaluate such ...

Parkinson's disease is characterized by a depletion of dopamine (DA) neurons in the nigrostriatal pathway. Stereotaxic injections of 6-hydroxydopamine (6-OHDA), a selective neurotoxin, into either the medial forebrain bundle or the substantia nigra result in a massive DA denervation of the nigrostriatal pathway. Following unilateral nigrostriatal DA depletion, hemiparkinsonian animals develop a...

Several lines of evidence show that homocysteine (Hcy) levels are increased in blood and CSF of patients with Parkinson's disease. B vitamins are necessary for Hcy metabolism and their deficiencies cause hyperhomocysteinemia and neurodegeneration. In present study, effect of B vitamin supplementation on the severity of 6-hydroxydopamine (6-OHDA)-induced Parkinsonism was investigated. Rats were ...

Background & Aims: With regard to the neuroprotective effect of creatine in some neurological disorders like cerebral ischemia, this study was conducted to evaluate the effect of creatine in an experimental model of Parkinson’s disease (PD). Involvement of oxidative stress was also assessed. Methods: In this experimental study, male rats (n = 40) were divided into 5 groups, i.e. sham-operated (...

Unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway produce side-biased motor impairments that reflect the motor deficits seen in Parkinson's disease (PD). This toxin-induced model in the rat has been used widely, to evaluate possible therapeutic strategies, but has not been well established in mice. With the advancements in mouse stem cell research we believe the require...

Opioids modulate brain dopaminergic function in various experimental paradigms. This study used the rotational model of behavior in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal pathway to investigate this interaction. Doses of two presynaptically acting dopaminergic drugs, amphetamine and cocaine, were coadministered with several doses of the mu opioid agonist, mo...

A basic assumption of the 'rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal dopamine (DA) system. However, we report here that if the normally 'dominant ' striatum is partially depleted of DA the majority of rats turn contraversive when given AMPH, i.e. in the opposite direction ...