In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuat...

there is a paucity of research on hydrochloride heroin addiction and its effects on human executive functions. Executive system is a cognitive system that controls and manages cognitive processes. This system is named as the executive function, supervisory attentional system, or cognitive control. This system is also used to describe a defined collection of brain processes that are responsible ...

Heroin overdose deaths are preventable. Overdose prevention in Australia has largely rested on opioid substitution treatment supplemented with outreach services and education for injecting drug users (IDUs) about overdose risks and responses. We believe now is the time to make naloxone hydrochloride (Narcan ®) available to Australian IDUs to help prevent overdose deaths. At the end of 2000 hero...

The drugs of abuse cocaine (C), heroin (H), and morphine (M) have been studied to enable understanding of the occurrence of cocaine-opioid interactions at a molecular level. Electrochemical, Raman, and NMR studies of the free drugs and their mixtures were used to study drug-drug interactions. The results were analyzed using data obtained from quantum-mechanical calculations. For the cocaine-mor...

RATIONALE Methadone and buprenorphine are among the most widely employed pharmacological treatments currently available for opioid addiction. Cognitive effects of buprenorphine in abstinent heroin abusers are nevertheless far from being understood. METHODS Neuropsychological performance of 18 buprenorphine-maintained patients (BMP) was evaluated relative to that of 32 currently abstinent hero...

BACKGROUND Recent events in the United States have led to increased security at national borders, resulting in an unexpected increase in drug seizures. In response, drug smugglers may begin using children as couriers, including using them as "body packers." OBJECTIVE To look at the occurrence of body packing, the concealing of contraband within the human body, which is well documented in adul...

ErOIN, or diacetyl morphia, is chiefly used in this country as Sedati^e in cases of troublesome cough, and is generally given ^ the hydrochloride in a mixture. I am informed, however, by essrs. Burroughs and Wellcome, that it is largely used at the Plesent time hypodermically, chiefly, I imagine, for the relief of Pain or the control of asthma. It is desirable, therefore, that rriedical men sho...

spectrophotometric and electrochemical studies were successfully used in quantitative analysis of amitriptyline hydrochloride (ath) and nortriptyline hydrochloride (nth). conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. two new methods using spectrophotometry are dascribed for the determination of (ath) and (nth) with potassium b...