EVER since 1846, when Boston dentist William Thomas Green Morton, in front of a group of skeptical surgeons, administered diethyl ether to a patient about to undergo a surgical operation, we have known that clinical anesthesia is no humbug, and we have been interested in its mechanism of action. In this issue of ANESTHESIOLOGY, Boveroux et al. provide some exciting new data that shed some light...

Initiation is often assumed to be rate-limiting for protein synthesis, but the presence of rare codons nonetheless can influence protein levels. In this issue of The EMBO Journal, Chu et al report that when rare codons are positioned near the start of the coding region, 'liberation' of the initiation codon for loading of the next 40S subunit may be rate‐limiting for initiation and therefore ove...