conclusions according to this observation, another factor such as oncogenes activity may cause cancer in samples but ct genotype of mthfr can be considered as an effective factor in creating cancer. results methylation status of e-cadherin gene numbers of methylated cases in the cancer group were equal to one and unmethylated cases equal to 33 and numbers of unmethylated cases in the non-cancer...

OBJECTIVE Previous studies have shown that Fructus Ligustri Lucide (FLL) can be used to anti-cancer. However, the mechanism by which FLL mediate this effect is unclear. In the present study, aqueous extracts of FLL induced cell apoptosis in human gastric carcinoma cell was investigated. METHODS The cell viability was detected by the CCK8 assay. The cell apoptosis was assessed by annexin V-PI ...

It has been previously reported (M. Yashiro et al., Jpn. J. Cancer Res., 84: 883-886, 1994) that a growth factor secreted by human gastric fibroblasts stimulated proliferation of human scirrhous gastric carcinoma cells in vitro, suggesting a similar paracrine action in the gastric submucosa. The present study established the identity of the growth factor as keratinocyte growth factor (KGF). Inc...

BACKGROUND Human runt-related transcription factor gene 3 (RUNX3) is considered as a possible candidate of tumour suppressor gene in human gastric carcinoma. MATERIALS AND METHODS To investigate the RUNX3 protein expression in human gastric mucosa and carcinoma, we generated a polyclonal antibody, AS251, which recognized amino acid sequences from 251 to 266 of human RUNX3. The AS251 antibody ...

The objective of the current study was to investigate the significance and biologic characteristic of neuroendocrine cell differentiation (NED) in gastric carcinoma by comparing the prognosis and clinicopathologic characteristics between patients with or without NED. Retrospective analyses of neuroendocrine markers, neuron specific enolase (NSE), chromogranin A (CgA), and synaptophysin (Syn) we...

Rabbits were immunized with the supernatant of a homogenate of non-cancerous gastric mucosa to obtain an antiserum. This antiserum, after absorption by human jejunal mucosa and liver tissue, produced precipitin lines with the supernatants of homogenates of gastric carcinoma and gastric mucosa. Fluorescent staining was attempted using this antiserum. Well-stained cytoplasms were observed in cell...

Purpose: We sought to determine whether cyclosporin-A (CsA) enhances docetaxel [Taxotere (TXT)]induced apoptosis in human gastric carcinoma cells, and, if so, to determine the relation between this apoptosis and nuclear factorB (NFB) activation. Experimental Design: Two human gastric carcinoma cell lines (GCTM-1 and MK-1), a human embryonic pulmonary fibroblast cell line, and human umbilical ve...

500 cases of Esophago-Gastroscopy were evaluated at the Shahid Moddares teaching and research medical center. Endoscopic diagnosis were:  38% Gastritis, 24% Duodenal Ulcer, 8% Esophageal Carcinoma, 6% Gastric Carcinoma, 6% Gastric Ulcer, 6% Hiatal Hernia, 3% Esophageal Varises.  In 68% of these cases Gastroscopy findings were in Agreement with Radiology reports. 

BACKGROUND The caspase-associated recruitment domain-containing protein (CARP) is expressed in almost all tissues. Recently, the tumor-suppressive function of CARP was discovered and attracted increasing attention. This study aimed to investigate the role of CARP in the carcinogenesis of human gastric carcinoma. METHODOLOGY/PRINCIPAL FINDINGS Compared with normal gastric tissue, the downregul...

In the recent years one of the common causes of cancer related deaths in humans is associated with the development of gastric carcinoma leading to gastric cancer. It had long before reported that the potent agent that is intimately related with the gastric cancer is the infection of the bacterium Helicobacter pylori (H. pylori). H. pylori infection in humans is characterised by the development ...