mechanism of the binding of lomefloxacin (lmf) with human serum albumin has been studied at physiological ph (7.4) using fluorescence spectroscopic technique. lmf is a third-generation fluoroquinolone antibiotic that exhibits striking potency against a broad spectrum of gram-negative and gram-positive bacteria through inhibition of dna gyrase. lomefloxacin is a drug that is excreted in urine an...

To investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([Pd(phen)(R-gly)]NO3, R = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. These drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. Human serum albumin is also ...

to investigate the interaction and adsorption of drug and carbon nanotube on human serum albumin, three anti-cancer drugs ([pd(phen)(r-gly)]no3, r = methyl, propyl and amyl) with different hydrophobic tails and anticancer activities were selected. these drugs have better anti-tumor activity and less side effects than that known cis-platinum drug. human serum albumin is also important for drug d...

introduction : albumin, one of the most important plasma proteins, has a difficult process of synthesis and production. we compared two different methods for albumin purification: carboxymethyl cellulose (cm cellulose) resin exchange and diethylaminoethyl cellulose (deae cellulose) resin exchange in order to determine which resin could be more beneficial. materials and methods : two ion exchang...

albumin has a fundamental role in human body. its main tasks in blood are to regulate osmotic blood pressure, maintaining the ph, and transporting metabolites and drugs throughout the vascular system.  pharmacological studies of the interaction of drugs on hsa are important due to structural and functional changes of this vital protein; thus, here in this research the effect of valproate as a c...

human serum albumin (hsa) is an important protein that carries variety of substances like some hormones and drugs in blood. pharmacological studies of the interaction of many drugs and hsa are reported during several decades, specially recently years. interaction of cortisol and fluoxetine hydrochloride (flx) (as a common anti-stress drug) with hsa (as their carrier in blood) has been studied s...

thermal conformational changes in human serum albumin (hsa) in present with a 10 mm phosphate buffer, at ph=7 have been investigated via circular dichroism (cd) and uv spectroscopic methods. the results indicate that temperature in a range of 25oc to 55oc could induce a reversible conformational change in the structure of hsa. the hsa phase transition corresponds to the physiological and pathol...

background: the purpose of this study was to compare the three different strategies, intravenous (iv) hydroxylethyl starch (hes), iv human albumin (ha), and oral cabergoline (cb) in the prevention of ovarian hyperstimulation syndrome (ohss). materials and methods: in this prospective randomized clinical trial, 91 women at high risk of developing ohss were allocated into the three groups, group ...