Four monoclonal antibodies, human T cell leukemia-lymphoma virus (HTLV) 6, 7, 8, and 9, which react with the 24,000 dalton internal core protein of HTLVI, have been developed. These monoclonal antibodies reacted with only HTLV-infected cells and not with a broad spectrum of normal, neoplastic, mitogen-stimulated, or virus-infected cells and tissues. HTLV 6, 7, 8, and 9 identified at least two d...

T HE HUMAN T-cell lymphotropic viruses type I and type II (HTLV-I and HTLV-II) are closely related human retroviruses and have similar biological properties, genetic organization, and tropism for T lymphocytes. They were the first 2 retroviruses to be identified in humans in 19801 and 1982, respectively? They belong to the Oncovirinae subfamily, are typically lymphoproliferative, and are able t...

OBJECTIVES HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present...

Article type: Original article Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in di...

Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic inammatory disease of the spinal cord in which HTLV-I Tax-speciŽc cytotoxic T lymphocytes (CTL) have been suggested to be immunopathogenic. However, it is unknownwhether the HTLVI-speciŽc CTL in the central nervous system differ from those in the periphery. We investigated funct...

This report is an analysis of results provided to the Centers for Disease Control and Prevention (CDC) by participant laboratories in the Model Performance Evaluation Program (MPEP) after they tested the human T-lymphotropic virus types I and II (HTLV-I/II) performance evaluation samples shipped to them on May 5, 1997. Testing results for this analysis were provided by 185 (86.4%) of 214 labora...

There are continuing concerns over the safety of the nation's and the world's blood supply. The allogeneic blood supply is tested for antibodies to HIV1/2, HTLVI/II, hepatitis B, hepatitis C (HCV) and syphilis. Testing is also performed for donor ALT (SGOT) levels, for the presence of hepatitis B surface antigen, human immunodeficiency virus (HIV) p24 antigen and, using nucleic acid amplificati...

Until recently, simplicity and uniformity of design appeared to be universal features of retroviruses. Most retroviruses thrive with a few open reading frames in their genomes, all devoted to major constituents of virus particles: core proteins, envelope glycoproteins, and virionassociated catalytic proteins (reverse transcriptase, integrase, and protease). In the life cycle of the usual retrov...

Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases.  Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the pre...