Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...

Crossed reflex of limbs has been hitherto observed mainly in decerebrate or spinal animals. In man it was only recognized in pathological cases. The author, however, succeeded in this study in finding a suitable arrangement, in which the crossed reflex involving four limbs could be elicited and recorded even in healthy human subjects. As has been known since the last century, cutaneous stimulat...

purpose: microgravity causes major changes in various systems of the body in space, such as shift in cerebrospinal fluid, decreased red blood cells count, and electrolyte loss. these complications are very important in space and we should find new approaches to prevent the side effects of microgravity in astronauts. materials and methods: this experimental study was conducted on 21 adult male r...

Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine oxidative stress in mice. The antiepileptic potential (10, 20, or 30 mg/kg/i.p.) pentylenetetrazole (PTZ; 85 mg/kg) with i.p. route administration, strychnine (STR; 75 route, pilocarpine (400 s.c...

Purpose: Microgravity causes major changes in various systems of the body in space, such as shift in cerebrospinal fluid, decreased red blood cells count, and electrolyte loss. These complications are very important in space and we should find new approaches to prevent the side effects of microgravity in astronauts. Materials and Methods: This experimental study was conducted on 21 adult ma...

To evaluate the anticonvulsant activity of the aerial parts of Verbena officinalis used traditionally by local Iranians for the treatment of convulsion. The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ) and maximal electroshock (MES) induced seizures in mice. Diazepam was used as reference drug. In addition, for investigating the mechanism of V officinalis in P...

The anticonvulsant effects of 3,4-Dimethoxy toluene (DMT), the major constituent of the date palm (Phoenix dactylifera L.) spathe, were investigated using pentylenetetrazole (PTZ), picrotoxin (Pic), nicotine (Nic) and maximal electroshock (MES)-induced seizure models. In PTZ (85 mg/kg)-induced seizures, the intraperitoneally injection of DMT at a dose of 100 mg/kg significantly delayed the onse...

background: lippia citriodora kunth is one of the iranian traditional medicines for the treatment of convulsive disorders. the goal of this study is to investigate the anticonvulsant activity of the plant’s leave ethanolic extract against electro‑ and chemoconvulsant‑induced seizures in mice. methods: the anticonvulsant activity of the extract (200, 400, 800 mg/kg, per os, p.o.) was investigate...

Anticonvulsant activity of the methanolic extract of Prosopis Cineraria (Linn) Druce stem barks was studied against maximal electro shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in mice. The extract suppressed hind limb tonic extensions (HLTE) induced by MES and also exhibited Protector Effect in PTZInduced Seizures. In conclusion, the methanolic extract of Prosopis Cineraria (Li...