The NH2-terminal amino acid sequences have been determined by automated Edman degradation for the heavy and light chains of five monoclonal IgM anti-DNA autoantibodies that were produced by human-human hybridomas derived from lymphocytes of two patients with systemic lupus erythematosus. Four of the antibodies were closely related to the idiotype system 16/6, whereas the fifth antibody was unre...

The use of artificial intelligence (AI) in sensor analytics is entering a new era based on the ubiquitous embedded connected devices. This transformation requires adoption design techniques that reconcile accurate results with sustainable system architectures. As such, improving efficiency AI hardware engines as well backward compatibility must be considered. In this paper, we present Hybrid-Fl...

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is characterised by its heterogeneity, which extends to definition. How HFpEF defined has important consequences for recruitment into clinical trials and outcomes, several definitions have been used across guidelines trials. Purpose The aim of this study was characterise a cohort newly-diagnosed community patients their ...