Background. To determine the overall incidence of hepatotoxicity in children and risk factors such as age, gender, and their outcomes. Methods. Patients who were admitted to the Pediatric Infectious Disease Clinic during the period from December 2009 through August 2013 with the diagnosis of latent TB infection were included in this study. Isoniazid hepatotoxicity was classified according to th...

there is now clear evidence that the atherosclerotic process begins in childhood. a major and important cause of atherosclerosis and coronary heart disease (chd) is elevated cholesterol level. in order to clarify the sigificance of elevated total cholesterol (tc) in children who live in tehran, we measured the lipid profiles including tc triglyceride (tg), and high density lipoproteein choleste...

a storke is the sudden onset of focal neurologic deficit from a vascular mechanism and is the 3 rd cause of death in developed countries. this study was carried out to evaluate the known risk factors of stroke and their effect on the onset of it in shahid behesti hospital in kashan in 1998. the descriptive strategy of this study was conducted on 300 patients with cva, that their illness was doc...

the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...

The central role of the liver in drug metabolism sets the stage for drug-related hepatotoxicity. The incidence of hepatotoxicity associated with non-narcotic analgesics is low, but their widespread use both prescription and over-the-counter-makes analgesic-associated hepatotoxicity a clinically and economically important problem. Hepatotoxicity is considered a class characteristic of nonsteroid...

AIM To evaluate the tolerability and efficacy of erlotinib treatment in advanced non-small cell lung cancer (NSCLC) patients who had previously experienced severe hepatotoxicity after gefitinib treatment. PATIENTS AND METHODS Twenty-five NSCLC patients with epidermal growth factor receptor (EGFR) mutation were initially treated with gefitinib (250 mg/day). However, 7 of these experienced seve...

introduction: hyperlipidemia is a major cardiovascular risk factor. this survey has been performed to determine the prevalence of hyperlipidemia in the 17th zone of tehran. methods: 1573 individuals 25-64 aged were recruited from the inhabitants of the 17th zone of tehran through one stage cluster sampling. standard questionnaires were filled out for all of the participants. lipid profile was c...

variations in phosphatidate phosphohydrolase (pap) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. pap activity in adipose tissue was elevated by 61% during pregnancy. the increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). estradiol injecting into non-pregnant rats increased ...