background: cirrhosis is a pathologically defined entity associated with a spectrumof characteristicmanifestations.the cardinal pathologic features reflect irreversible chronic injury of the hepatic parenchyma and include extensive fibrosis in association with the formation of regenerative nodules.autonomic dysfunction is a frequent and important complication of cirrhosis. the risk of mortality...

The effect of hepatic dysfunction, defined as abnormal serum bilirubin level, on oral cyclosporin (CSP) pharmacokinetics was examined in 28 marrow transplant patients who received CSP for prophylaxis of graft-v-host disease. Serum CSP concentrations were measured by radioimmunoassay. Forty-one concentration-time courses were studied, divided among patients with no (less than 1.2 mg/dL), mild (1...

OBJECTIVE In critically ill patients, hepatic dysfunction is regarded as a late organ failure associated with poor prognosis. We investigated the incidence and prognostic implications of early hepatic dysfunction (serum bilirubin >2 mg/dL within 48 hrs of admission). DESIGN Prospective, multicenter cohort study. SETTING Thirty-two medical, surgical, and mixed intensive care units. PATIENT...

Hepatic dysfunction is often observed in patients with Graves' hyperthyroidism. The aims of this study were to investigate the risk factors for hepatic dysfunction and to analyze the efficacy of I (radioactive iodine-131) treatment. In total, 2385 patients with Graves' hyperthyroidism (478 males, 1907 females; age 42.8 ± 13.5 years) were involved in our study. Of these, 1552 cases with hepatic ...

BACKGROUND AND AIMS Major liver resection incurs a risk of postoperative liver dysfunction and infection and there is a lack of objective evidence relating residual liver volume to these complications. PATIENTS AND METHODS Liver volumetry was performed on computer models derived from computed tomography (CT) angioportograms of 104 patients with normal synthetic liver function scheduled for li...

introduction anabolic-androgenic steroids (aas), a synthetic derivate of testosterone, have become a popular drug among athletes and bodybuilders to enhance muscle mass and improve the athletic performance. many pathological effects such as hepatic and endocrine dysfunction, behavioural changes and cardiovascular complications have been reported. case report within these ast ones, we find an in...

Septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. The severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. The direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as O 2 - , p...

Mol. Nutr. Food Res. 2023, 67, 202200158 DOI: 10.1002/mnfr.202200158 Hepatic encephalopathy (HE) is a neurotoxic disease with spectrum of neuropsychiatric abnormalities that develops as result hepatic dysfunction. Chitooligosaccharides (COS) an oligosaccharide possesses prominent biological activities including incalculable hepatoprotective and neuroprotective effects. Here, COS has been proved...

Hepatic dysfunction is commonly observed in subjects with hyperthyroidism. Hepassocin a hepatokine playing an important role metabolic diseases and exhibiting hepatic protective effect. Nevertheless, the relationship between hepassocin hyperthyroidism was still unknown. In present study, total of 36 Graves’ disease were enrolled, we found that alanine aminotransferase (ALT) levels significantly...