Methemoglobinemia and hemolytic anemia are the most prominent side-effects of a wide variety of arylamine drugs including agricultural and industrial chemicals. Symptoms of this hemotoxicity include headache, fatigue, dizziness respiratory and cardiac arrest, and possibly death. Parent compounds are usually converted to their toxic metabolites (N-hydroxylamine) and react with oxyhemoglobin with...

Background: The skin mucus layer of fish is endowed with biologics including, Antimicrobial peptides (AMPs) that offer a first line defence against pathogens. Such can either inhibit bacterial growth or completely kill the bacteria and hence are regarded as viable alternative to traditional antibiotics, in addressing ever-increasing incidences antimicrobial resistance. However, one major hurdle...

Hepatitis C-associated liver failure is the most common indication for liver transplantation, with virological recurrence near ubiquitous. Approximately 30% of HCV-infected recipients will die or lose their allograft or develop cirrhosis secondary to hepatitis C recurrence by the fifth postoperative year, with the proportion increasing with duration of follow-up. Strategies for minimizing the f...

background : there has been a rapid increase in cancer among sudanese citizens from 1999 until this year. at least 80% of all patients who undergo chemotherapy will develop anemia as a complication. this inpatient analytical comparative study aims to examine the possible association between hemotoxicity and various chemotherapy regimens in sudanese children diagnosed with retinoblastoma. method...

Aim: Kefir is a probiotic/prebiotic drink with an exotic flavor, which has been traditionally produced fermented milk and kefir grains containing mixture of bacteria yeast. Cyclophosphamide (CPx), are generally limited due to numerous unwanted severe acute toxic side-effects. For this purpose, the cell-protective effects kefir, natural probiotic known for its antitumor antioxidant properties, o...

Introduction: Trypanosoma cruzi is the agent of Chagas’ disease and affects approximately 6-8 million people worldwide. The search for new anti-T. drugs are relevant because only two exist actually. objective this study was to investigate effect extracts from seeds Lonchocarpus cultratus on T. cruzi, its cytotoxicity as well elucidate chemical profile.
 Methodology: characterization done u...