Significance Human cytomegalovirus (HCMV) reactivation is a major cause of posttransplant morbidity/mortality. One approach toward reducing this purging the transplant donor and/or recipient latently infected cells prior to stem-cell or organ harvest/engraftment. Our findings show involvement host bromodomain (BRD) proteins in regulation HCMV latency and reactivation. Bromodomain extra-terminal...

Human cytomegalovirus (HCMV) causes persistent infection in humans and severe diseases in fetus andimmunocompromised individuals. Although HCMV is not currently implicated in human cancer, emerging evidence suggests that HCMV infection might be specifically associated with some human malignancies including glioma. Glioma is one of the most common brain tumors affecting children and adults. In t...

Previous studies indicated that elevated serum levels of Interleukin -18 (IL-18) and human cytomegalovirus (HCMV) antibodies have a fundamental role in the pathogenesis Type I diabetic mellitus T1DM. Therefore, aim current study was to investigate possible overlap between Interleukin-18 with The (45) T1DM patients healthy controls were used detect IL-18 an ELISA Kit HCMV cobas c411 apparatus fo...

Introduction Human cytomegalovirus (HCMV) reactivation causes complications in immunocompromised patients after hematopoietic stem cell transplantation (HSCT), significantly increasing morbidity and mortality. Adaptive Natural Killer (aNK) cells undergo a persistent reconfiguration response to HCMV reactivation; however, the exact role of aNK memory surveillance remains elusive. Methods We empl...

accurate and rapid diagnosis of human cytomegalovirus (hcmv) disease in immunocompromised patients has remained as a challenge. quantitative competitive pcr (qc-pcr) methods for detection of hcmv in these individuals have improved the positive and negative predictive values of pcr for diagnosis of hcmv disease. in this study we used qc-pcr assay, using a co-amplified dna standard, to quantitate...

Human cytomegalovirus (HCMV) is a ubiquitous virus whose sole host is humans. Since HCMV can contagion from person to person through numerous ways, vast populations of humans are infected. HCMV infections can potentially have a range from asymptomatic infection in immuno-competent hosts to life-threatening diseases in organ recipients and patients with AIDS. The present article reviews the occu...

objective: human cytomegalovirus (hcmv) is a beta-herpesvirus that causes persistent infection in humans, as well as severe disease in fetuses and immunocompromised individuals. although hcmv is not currently causally implicated in human cancer, emerging evidence suggests that hcmv infection may be specifically associated with malignancies such as gliomas. gliomas are one of the most common bra...

Using a specific and sensitive polymerase chain reaction method, we detected reliably the presence of human cytomegalovirus (HCMV) DNA directly in serum samples collected at an early stage of HCMV infection, even before immunoglobulin M (IgM) antibodies were measurable. HCMV DNA was detected in serum from all patients with active HCMV infection; in 91% of these patients, HCMV DNA was found in t...

Background and Aim: Human cytomegalovirus (HCMV) has the potential for oncogenicity and has been associated with many malignancies, including prostate cancer. This study aimed to investigate the genomic prevalence of HCMV in prostate cancer tumors. Materials and Methods: In this case-control study, 31 patients with prostate cancer were enrolled along with 31 patients with benign prostate cance...