the archaeological evidence suggests that iran has been one of the first origins of sheep domestication in the world. this study aims to investigate the genetic diversity of indigenous iranian sheep breeds using mitochondrial dna (mtdna) and to explore the evolutionary history of sheep domestication in iran. single nucleotide polymorphism (snp) markers in the control region of mtdna were used t...

Lactoferrin (Lf) is a bioactive protein present in all external secretions such as milk that plays important role in the innate host defense. Therefore, the Lf has a major role in bovine mammary gland defense during mastitis. In this study, 5’-flanking region of bovine Lf gene containing three single nucleotide polymorphisms (SNPs) at positions −602 (T/G), −600 (A/G) ...

Phlebotomus papatasi is an important vector of L. major in Iran. P. papatasi was collected from peridomestic animal shelters, inside and around the houses and also the nearby burrows of the gerbil reservoir hosts, Rhombomys opimus, in several provinces in Iran. Mitochondrial Cytochrome b (Cyt b) of sandflies, which is a maternally-inherited gene marker, was used to see if there is any "isolatio...

Objective(s):Organic anion transporter polypeptide 1B1 (OATP1B1) encoded by solute carrier organic transporter 1B1 (SLCO1B1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. Aim of this study was to investigate the frequencies of functionally significant SNPs (388A>G and 521T>C) and their haplotypes in 6 ethnic groups of ...

Pedunculate oak (Quercus robur L.) is one of the main forest forming species in Republic Belarus. Its population genetic structure was formed under influence various migration processes. Six chloroplast DNA loci (µdt1, µdt3, µdt4, µcd4, µcd5 and µkk4) were used for genogeographic study. The material analysis collected 100 stands (2325 samples); 18 allelic variants identified, which are grouped ...

A new test of inheritance, S, is proposed, which uses information from affected as well as unaffected siblings in the fam­ ily. The siblings are analyzed in terms of similarities of haplotypes. The distribution of the proposed S­test is derived under the null hypothesis of random inheritance. Mean and variance are obtained for the distribution. The test is then applied to data sets publ...

Utilization of fecundity genes such as GDF9 and BMP15 can help improve reproductive traits in sheep breeding programme. To evaluate effects of missense mutations on protein function, the polymorphisms of GDF9 and BMP15 genes were screened in twelve mehraban sheep using DNA sequencing, followed by protein structure modeling. Six single nucleotide polymorphism (SNPs) known as FecG mutations (G1-G...

the genetic variation and population structure of narrow-clawed crayfish (astacus leptodactylus) was examined by means of polymerase chain reaction (pcr) restriction fragment length polymorphism (rflp) analysis of the cytochrome oxidase subunit i (coi) of mitochondrial dna. a total of 194 adult specimens were collected from seven sample sites including, two in the south caspian sea and one each...

Relevance – it is promising to develop a system for the diagnosis and prevention of primary open-angle glaucoma (POAG), which would be based on determination constitutive propensity factors able predict onset progression disease. The aim study was model predicting rate depending gender endothelial NO-synthase (NOS3) gene polymorphism. There were genotyped 153 patients with POAG aged 36-84 years...

The genetic diversity and phylogenetic structure was analyzed in Marghoz goat population by mitochondrial DNA sequences. Phylogenetic analysis was carried out using hyper variable region 1 (968 bp) obtained form 40 animals. Marghoz goat proved to be extremely diverse (average haplotype diversity of 0.999) and the nucleotide diversity values 0.022. A total of 40 Marghoz goats were grouped into s...