In Japan, a rapid pace of aging coupled with the lower birth rates causes the decrease of the population especially in rural area, which leads to the problems with the delivery of healthcare services. We investigated the relationship between the geographical accessibility (time and distance) and the utilization rate of outpatient services in the elderly by major disease groups in Tokushima pref...

For a prime p, we call p regular when the class number hp = h(Q(ζp)) of the pth cyclotomic field is not divisible by p. For instance, all primes p ≤ 19 have hp = 1, so they are regular. Since h23 = 3, 23 is regular. All primes less then 100 are regular except for 37, 59, and 67. By the tables in [6], h37 = 37, h59 = 3 · 59 · 233 and h67 = 67 · 12739. It is known that there are infinitely many i...

Hulme, J. T., and C. H. Orchard Effect of acidosis on transient outward potassium current in isolated rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 278: H50–H59, 2000.—The effect of acidosis on the transient outward K1 current (Ito) of rat ventricular myocytes has been investigated using the perforated patch-clamp technique. When the holding potential was 280 mV, depolarizing p...

Phytases are used for feeding monogastric animals, because they hydrolyze phytic acid generating inorganic phosphate. Aspergillus niger 3-phytase A (PDB: 3K4Q) and 3-phytase B (PDB: 1QFX) were characterized using bioinformatic tools. Results showed that both enzymes have highly conserved catalytic pockets, supporting their classification as histidine acid phosphatases. 2D structures consist of ...

Numerical simulation is necessary to understand natural phenomena, make assessments and predictions in various research and engineering fields, develop new technologies, etc. New algorithms are needed to take advantage of the increasing computational resources and utilize the emerging hardware and software infrastructure with maximum efficiency. Adaptive numerical discretization methods can acc...

Notay K, Incognito AV, Millar PJ. Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study. Am J Physiol Heart Circ Physiol 313: H59–H65, 2017. First published May 5, 2017; doi: 10.1152/ajpheart.00163.2017.—Acute dietary nitrate (NO3 ) supplementation reduces resting blood pressure in healthy normotensives. This re...

BACKGROUND EGF receptor variant III (EGFRvIII) is the most common variant of the EGF receptor observed in human tumors. It results from the in frame deletion of exons 2-7 and the generation of a novel glycine residue at the junction of exons 1 and 8. This novel juxtaposition of amino acids within the extra-cellular domain of the EGF receptor creates a tumor specific and immunogenic epitope. EGF...