APOBEC3G is a protein family that interferes with the replication of the HIV virus by altering the genomic sequence of the virus. To combat this, the virus evolves a countermeasure in the form of a protein called Viral Infectivity Factor (vif) binds to APOBEC to reduce its effectiveness. In vitro, dilutions from zero to 1mg of APOBEC3G are injected into HIV infected cells. The cells’ DNA sequen...

We describe here the first crystalline hydrogen-bonded organic framework made from complementary guanine and cytosine nucleobases.

2-Aminopurine (2AP) is a fluorescent nucleobase analogue of the DNA adenine and can be inserted in place into nucleic acids with minimal structural perturbation. The 2-aminopurine selectively excited, fluorescence observed used as sensitive probe for local structure, addition selective ionization within acid possible once formed ionized will oxidize nearby guanine bases, providing route to stud...

DNA G-Quadruplex is highly sensitive to oxidation as their structures include $$\pi$$ -stacked guanine quartets allowing fast hole transfer between the nucleobases. These transfers can be described using vertical energy gap and electronic coupling different diabatic states at play in a pair. Using classical molecular dynamics simulation constrained DFT/MM implementation deMon2k, we determine th...

the binding energy and thermodynamic parameters of cis- platinum di ammino chlorine (cis-[pt(nh3)2cl]+) and trans- platinum di ammino chlorine (trans- [pt(nh3)2cl]+) complexes withguanine has been studied by density functional theory (dft) calculations in water. the bindingenergies (ebin) of cis- and trans-[pt(nh3)2clg]+ are calculated to be 79.38 kcal/mol and 74.98kcal/mol, respectively. the b...