*Corresponding Author: [email protected] Abstract The aim of the present study was to investigate effects of testosterone propionate (TP) on the histological properties of heart in gonadectomized rabbits. Fifteen New Zealand white rabbits, 2.5-month-old, were selected in this study. The animals were divided into 3 operation groups: sham-operated control animals (Co), gonadectomy animals (...

Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vulnificus are males. Using the rat, we have developed a model for V. vulnificus...

Attempts to determine the influence of testicular hormones on learning and memory in males have yielded contradictory results. The present studies examined whether testicular hormones are important for maximal levels of spatial memory in young adult male rats. To minimize any effect of stress, we used the Object Location Task which is a spatial working memory task that does not involve food or ...

testosterone enanthate (te) is used by many athletes as a muscle builder. previous studies showed that high concentration of the drug in plasma may affect the natural function of endocrine glands, specially the secretion of the adrenocortical hormones. the objective of the present study was to examine the effects of high concentration of te on histometrical structure of adrenal cortex in male r...

There are various sex differences in sleep/wake behaviors mice. However, it is unclear whether there sleep homeostasis and arousal responses gonadal hormones involved these differences. Here, we examined under baseline condition, after deprivation by gentle handling, to repeated cage changes male female C57BL/6 mice that hormonally intact, gonadectomized, or gonadectomized with hormone suppleme...

INTRODUCTION Mood disorders such as anxiety and depression are common following menopause and andropause. Lack of sex steroid hormones is suggested as the primary cause of these disturbances. The level of luteinizing hormone (LH) would also rise 3-4 times than normal in these people. The potential effects of LH on mood and cognitive symptoms following menopause and andropause are still unknown....

Hypothalamic-pituitary-adrenal (HPA) activity is governed by glucocorticoid negative feedback and the magnitude of this signal is determined, in part, by variations in plasma corticosteroid-binding globulin (CBG) capacity. Here, in gonadectomized male rats we examine the extent to which different testosterone replacement levels impact on CBG and HPA function. Compared with gonadectomized rats w...

Differences in gender are in part responsible for the development of insulin resistance (IR) and associated hypertension. Currently, it is unclear whether these differences are dictated by gender itself or by the relative changes in plasma estrogen and/or testosterone. We investigated the interrelationships between testosterone and estrogen in the progression of IR and hypertension in vivo in i...