Glioblastomamultiforme (GBM) is a highlymalignant human brain neoplasmwith limited therapeutic options. GBMs display a deregulated apoptotic pathway with high levels of the antiapoptotic Bcl-2 family of proteins and overt activity of the phosphatidylinositol 3-kinase (PI3K) signaling pathway. Therefore, combined interference of the PI3K pathway and the Bcl-2 family of proteins is a reasonable t...

Glioblastomamultiforme (GBM) is one of the most lethal forms of cancer, with a survival rate of only 13% to 27%within 2 years of diagnosis despite optimal medical treatment. We hypothesize that the presence of a unique IL-13Ra2 decoy receptor prevents GBM apoptosis. This receptor has a high affinity for interleukin13 (IL-13), binds the cytokine, and competitively inhibits the intracellular sign...

background : glioblastoma multiforme (gbm) or grade iv astrocytoma is the most common and lethal adult malignant brain tumor. several of the molecular alterations detected in gliomas may have diagnostic and/or prognostic implications, proteomics has been widely applied in various areas of science, ranging from the deciphering of molecular pathogen nests of discuses. method: we extracted protein...

Background: Broca’s and Wernicke’s areas, which are important language areas of brain, are commonly irradiated in patients with right frontal lobe glioblastomamultiforme (GBM). We aimed to compare two different treatment planning techniques in terms of the doses in the Broca’s and Wernicke’s areas for the patients with right frontal GBM. Materials and Methods: Two differ...

Many health professionals rely on journal articles to keep up with advances in their field because textbooks are often 1–2 years out of date by the time they come to press, and are far more expensive than the occasional PDF downloaded from a university library Web site. This 2-volume text on cytomegalovirus (CMV) is costly and cites data from before 2012, but provides a solid foundation on whic...

The DNA damage response (DDR) plays a crucial role in tumor development in different tissues. Here, we show that p53-binding protein 1 (53BP1), a key element of the DDR, is heterozygously lost in approximately 20% of human glioblastomamultiforme (GBM) specimens, primarily of the Proneural subtype, and low 53BP1 expression levels are associated with worse prognosis. We present evidence that 53BP...

BACKGROUND AND PURPOSE: There is significant interest in whether diffusion-weighted MR imaging indices, such as the minimum apparent diffusion coefficient, may be useful clinically for preoperative tumor grading and treatment planning. To help establish the pathologic correlate ofminimumADC, we undertook a study investigating the relationship betweenminimumADC andmaximum FDOPA PET uptake in pat...

BACKGROUND AND PURPOSE: Cu-diacetyl-bis(N-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features amongMR imaging and Cu-diacetyl-bis(N-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[C]methionine)-PET in gliomas. MATERIALSANDMETHODS: Weenrolled 23 patientswhounderwent Cu-diacetyl-bis(N-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who...