نتایج جستجو برای: gingerol

تعداد نتایج: 423  

Journal: :Cancer research 2009
Chul-Ho Jeong Ann M Bode Angelo Pugliese Yong-Yeon Cho Hong-Gyum Kim Jung-Hyun Shim Young-Jin Jeon Honglin Li Hualiang Jiang Zigang Dong

[6]-Gingerol, a natural component of ginger, exhibits anti-inflammatory and antitumorigenic activities. Despite its potential efficacy in cancer, the mechanism by which [6]-gingerol exerts its chemopreventive effects remains elusive. The leukotriene A(4) hydrolase (LTA(4)H) protein is regarded as a relevant target for cancer therapy. Our in silico prediction using a reverse-docking approach rev...

2017
Mehdi Bin Samad Md Nurul Absar Bin Mohsin Bodiul Alam Razu Mohammad Tashnim Hossain Sinayat Mahzabeen Naziat Unnoor Ishrat Aklima Muna Farjana Akhter Ashraf Ul Kabir J M A Hannan

BACKGROUND [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Leprdb/db diabetic mice, we investigated the...

Journal: :Oncogene 2005
Sue Ok Kim Joydeb Kumar Kundu Young Kee Shin Jin-Hong Park Myung-Haing Cho Tae-Yoon Kim Young-Joon Surh

[6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. The present study was aimed at unraveling the molecular mechanisms underlying previously reported antitumor promoting effects of [6]-gingerol in mouse skin in vivo. One of the well-recognized molecular targets for chemoprevention is cyclooxygenase-2 (COX-2) that i...

2006
Yon Jung Park Jing Wen Seungmin Bang Seung Woo Park Si Young Song

[6]-Gingerol, a major phenolic compound derived from ginger, has anti-bacterial, anti-inflammatory and anti-tumor activities. While several molecular mechanisms have been described to underlie its effects on cells in vitro and in vivo, the underlying mechanisms by which [6]-gingerol exerts anti-tumorigenic effects are largely unknown. The purpose of this study was to investigate the action of [...

2013
Xiao-Hong Li Kristine C. Y. McGrath Van H. Tran Yi-Ming Li Sravan Mandadi Colin C. Duke Alison K. Heather Basil D. Roufogalis

Calcium signals in hepatocytes control cell growth, proliferation, and death. Members of the transient receptor potential (TRP) cation channel superfamily are candidate calcium influx channels. NF κ B activation strictly depends on calcium influx and often induces antiapoptotic genes favouring cell survival. Previously, we reported that S-[6]-gingerol is an efficacious agonist of the transient ...

Journal: :Molecules 2017
Chi-Ming Liu Chiu-Li Kao Yu-Ting Tseng Yi-Ching Lo Chung-Yi Chen

Ginger has many bioactive compounds with pharmacological activities. However, few studies are known about these bioactive compounds activity in chemoresistant cells. The aim of the present study was to investigate the anticancer properties of ginger phytochemicals in docetaxel-resistant human prostate cancer cells in vitro. In this study, we isolated 6-gingerol, 10-gingerol, 4-shogaol, 6-shogao...

2015
Thing-Fong Tzeng Shorong-Shii Liou Chia Ju Chang I-Min Liu

Non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. The aim of the study was to investigate the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone), a bioactive ingredient of plants belonging to the Zingiberaceae family, on experimental models of NASH. In HepG2 cells, 6-gingerol (100 μmol/L) t...

2013
Xiao-Hong Li Kristine C. Y. McGrath Van H. Tran Yi-Ming Li Colin C. Duke Basil D. Roufogalis Alison K. Heather

Introduction. Hepatic inflammation underlies the pathogenesis of chronic diseases such as insulin resistance and type 2 diabetes mellitus. S-[6]-Gingerol has been shown to have anti-inflammatory properties. Important inflammatory mediators of interleukins include nuclear factor κ B (NF κ B) and cyclooxygenase 2 (COX2). We now explore the mechanism of anti-inflammatory effects of S-[6]-gingerol ...

Journal: :Molecules 2011
Jing Lu Shuang Guan Xue Shen Wenhui Qian Guoren Huang Xuming Deng Guanghong Xie

8-gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not on...

Journal: :Japanese journal of pharmacology 1988
I Kimura L R Pancho T Shiori M Kimura

The suppression of spontaneous Ca2+ spikes and isometric contractions by gingerols and their chemically related compounds was examined using the single sucrose gap method. Most of the congeners tested suppressed spontaneous contraction, which was not necessarily accompanied by the suppression of Ca2+ spikes. The most potent analogues for Ca2+ spike suppression were (+/-)-[6]-gingerol (0.3 mM) a...

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