PURPOSE β-Mangostin (BM) from Cratoxylum arborescens demonstrated various pharmacological activities such as anticancer and anti-inflammatory. In this study, we aimed to investigate its antiulcer activity against ethanol ulcer model in rats. MATERIALS AND METHODS BM was isolated from C. arborescens. Gastric acid output, ulcer index, gross evaluation, mucus production, histological evaluation ...

Due to the optimal composition of microelements, treatment with mineral waters "Vardzia" and "Zanavi" in patients suffering from gastroduodenitis led positive dynamics clinical symptoms disease. The anti-inflammatory, analgesic anti-toxic effect was revealed, structure mucous membrane stomach duodenum significantly improved, which normalization acid-producing function growth surface epithelium ...

This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent ...

Introduction: The effect of esophageal distension (ED) on gastric motility has been well documented, but a few investigations have been carried out on the effect of ED on gastric secretion. The aim of this study was to investigate the effect of ED on gastric acid and pepsin secretion and the mechanism(s) involved. Methods: Male adult Wistar rats (200-240 g) were anesthetized with urethane (1...

lated to play an important role in the pathogenesis of acute gastric mucosal injury induced by ischemia-reperfusion, stress, ethanol and anti-inflammatory drugs in rats. Furthermore, it has been suggested that free radicals generated by neutrophils may be important factors in delaying the healing of acetic acid-induced chronic gastric ulcers in these animals. It has been reported that polaprezi...

about 1.5-6 % of the patients with gastric and duodenal erosions admitted to i.c.u. are prone to gastrointestinal (g.i.) bleeding with its ensuing complications. routine prophylaxis with h2-blockers and anti-acid has been used in these high risk patients for decades. in this study we evaluated the effect of p.o omeprazole, a potent acid inhibitor with prolong effects on gastric ph.  patients wi...

The effect of alcoholic extract of Nigella sativa was investigated in rats to evaluate the anti-ulcer activity by using two models, i.e. pyloric ligation and aspirininduced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, free acidity, total acidity and ulcer index. The results indicate that the alcoholic extract significantly (P < 0.001) decre...

Both KB-5492, a new anti-ulcer agent, and cimetidine, administered orally at 25-200 mg/kg, dose-dependently prevented cysteamine (400 mg/kg, s.c.)-induced duodenal ulcers in rats with ED50 values of 63 and 40 mg/kg, respectively. Anti-ulcer doses of cimetidine, but not KB-5492, inhibited gastric acid hypersecretion induced by cysteamine (400 mg/kg, s.c.). In contrast, anti-ulcer doses of KB-549...

Chronic gastric inflammation developing after Helicobacter pylori (H. pylori) infection is responsible for either dyspeptic symptom relevant to gastritis/peptic ulcer or gastric tumorigenesis, in which acid suppressants, especially proton pump inhibitors (PPIs), play role in relieving dyspepsia as well as the eradication regimen. Among several mediators engaged in propagating gastric inflammati...