After Paul Broca localized the area responsible for producing speech in posterior region of left frontal lobe, John Hurling Jackson provided evidence showing presence different mental functions right and cerebral hemispheres. His theory was confirmed by discovery sensory language Carl Wernicke. Eduard Hitzig Gustav Fritsch identified motor cortex electrical stimulation. David Ferrier also used ...

Introduction: Amnesia or loss of memory is the cardinal hallmark of Alzheimer’s disease (AD), a progressive neurodegenerative disorder associated with ageing process. Although, AD had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. However, there has been a growing interest in the use of phytomedicines with m...

Objective(s): Studies have mainly assessed the effect of hyperglycemia on18F-fluorodeoxyglucose (FDG) uptake in the brain. In this study, we assessed the FDG uptake of the brain not only in normo- and hyperglycemia but also in hypoglycemia to compare the effect of various blood glucose levels on regional FDG uptake in the brain. Methods: </...

Cognitive planning, the ability to develop a sequenced plan achieve goal, plays crucial role in human goal-directed behavior. However, specific of frontal structures planning is unclear. We used novel and ecological task, that allowed us separate period from execution period. The spatio-temporal dynamics EEG recordings showed induced progressive sustained increase frontal-midline theta activity...

Cognitive maps come in all shapes and sizes. Here, we review the literature on cognitive their role novel inferences during decision making, focusing representations computations hippocampus, entorhinal cortex, ventral prefrontal cortex. We suggest that can be seen as balancing representational complexity online computational demand. Recent evidence suggests hippocampal formation orbital fronta...

introduction: amnesia or loss of memory is the cardinal hallmark of alzheimer’s disease (ad), a progressive neurodegenerative disorder associated with ageing process. although, ad had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. however, there has been a growing interest in the use of phytomedicines with m...

It is generally held that non-primary sensory regions of the brain have a strong impact on frontal cortex. However, the effective connectivity of pathways to frontal cortex is poorly understood. Here we microstimulate sites in the superior temporal and ventral frontal cortex of monkeys and use functional magnetic resonance imaging to evaluate the functional activity resulting from the stimulati...

20 Rapid and flexible interpretation of conflicting sensory inputs in the context of current 21 goals is a critical component of cognitive control that is orchestrated by frontal cortex. 22 The relative roles of distinct subregions within frontal cortex are poorly understood. To 23 examine the dynamics underlying cognitive control across frontal regions, we took 24 advantage of the spatiotempor...