Freeze casting with isopropanol (IPA)–H2O as a freezing agent has shown the potential to create porous scaffolds with enlarged pores. Though not experimentally proven, this effect has been suggested to be the result of non-stoichiometric structures called clathrate hydrates forming during the freezing process. In this manuscript, we build upon these results to provide experimental evidence of t...

The processing technique of freeze casting has been intensely researched for its potential to create porous scaffold and infiltrated composite materials for biomedical implants and structural materials. However, in order for this technique to be employed medically or commercially, it must be able to reliably produce materials in great quantities with similar microstructures and properties. Here...

One of the most promising applications of rapid freeze prototyping (RFP) is making metal parts by investment casting with the built ice parts. The integration of RFP and investment casting allows fast creation of complex net-shape metal parts directly from their CAD models. The advantages of doing so include no part geometric complexity limitation, no experience of parting line design and assem...

background: since the treatments of long tracheal leisions are associated with some limitations, tissue enginered trachea is considered as an alternative option. this study aimed at preparing a composite scaffold, based on natural and synthetic materials for tracheal tissue engineering. methods: nine chitosan silk-based scaffolds were fabricated using three freezing rates (0.5, 1, and 2°c/min) ...

Regeneration of neural injuries by formation of new axons and myelination to improve quality of patient life is undeniable difficulty in the world in which scientists examined different strategies from ancient times. Recently, 3D tissue engineering scaffolds simulated original extracellular matrix (ECM) and provide desirable substrate for cellular attachment, proliferation and differentiation. ...

A room temperature camphene-based freeze-casting method was used to fabricate hydroxyapatite/tricalcium phosphate (HA/TCP) ceramic scaffolds. By varying the solid loading of the mixture and the freezing temperature, a range of structures with different pore sizes and strength characteristics were achieved. The macropore size of the HA/TCP bioceramics was in the range of 100-200 microm, 40-80 mi...