the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...

objective(s):diabetes plays an important role in the induction of the liver injury. grape seed proanthocyanidin (gsp) have a wide range of medicinal properties against oxidative stress. in this study we evaluated antioxidant effects of gsp on liver in streptozotocin-induced diabetic rats. materials and methods: thirty male sprague–dawley rats were divided into three groups: control, untreated d...

Background: Stearic acid is known as a potent anti-inflammatory lipid. This fatty acid has profound and diverse effects on liver metabolism. The aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (APAP)-induced liver damage. Methods: Wistar rats were randomly assigned to 10-day treatment. Stearic acid was administe...

background: stearic acid is known as a potent anti-inflammatory lipid. this fatty acid has profound and diverse effects on liver metabolism. the aim of this study was to investigate the effect of stearic acid on markers of hepatocyte transplantation in rats with acetaminophen (apap)-induced liver damage. methods: wistar rats were randomly assigned to 10-day treatment. stearic acid was administe...

conclusions in conclusion, at measurement can be beneficial for the safety or recovery of malathion-induced toxic injury in liver tissue and liver mitochondria. results in liver tissue, the activity of lpo and cat was higher in the malathion group in comparison to controls. at reduced malathion-induced lpo, sod, cat, and gpx in rat liver. coadministration of at with malathion improved lpo, sod,...

Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...

Herb Induced Liver Injury (HILI) is a condition in which there aggression to the liver tissue after exposure substances present many different medications, dietary supplements, herbs and xenobiotics.

liver injury occurs with many drugs; therefore, a thorough work up is important for establishing the diagnosis. we report a case of trifluoperazine-induced cholestatic jaundice. a 44-year old male with schizoaffective disorder developed an increase in liver enzymes and jaundice after starting treatment with trifluoperazine. workup for other potential etiologies was negative.