Biological networks exhibit intriguing topological properties such as small-worldness. In this paper, we investigate whether the topology of a particular type of biological network, ametabolic network, is related to its robustness.Wedo so byperturbing ametabolic system in silico, one reaction at a time and studying the correlations between growth, as predicted by flux balance analysis, and a nu...

An analytical solution to the attenuation of flux within an integrating sphere due to spherical integrating source coating, exit port escape, and atmospheric absorption is derived employing a geometric probability distribution of completed sphere transits. This is used to determine the mean number of completed sphere transits and its variance. Equations that provide the attenuation ratios for t...

Advances in the field of bioinformatics have led to reconstruction of genome-scale networks for a number of key organisms. The application of physicochemical constraints to these stoichiometric networks allows researchers, through methods such as flux balance analysis, to highlight key sets of reactions necessary to achieve particular objectives. The key benefits of constraint-based analysis li...

Flux balance analysis (FBA) is an in silico metabolic analysis technique that has been used to identify potential drug targets in pathogens (disease-causing organisms) by determining essential biochemical reactions in these organisms [1]. To do this, previous studies have generally focused on completely removing each reaction in turn and checking if the pathogens can still survive, without quan...

Flux balance analysis (FBA) is a widely used computational method for characterizing and engineering intrinsic cellular metabolism. The increasing number of its successful applications and growing popularity are possibly attributable to the availability of specific software tools for FBA. Each tool has its unique features and limitations with respect to operational environment, user-interface a...