AIM Preterm infants requiring surfactant replacement have been treated using the INSURE technique, which requires sedation and comprises tracheal intubation, surfactant instillation and extubation. However, minimally invasive surfactant therapy (MIST) does not require sedation, minimises airway injury and avoids placing positive pressure ventilation on an immature lung. This study compared the ...

Background Intubation-Surfactant-Extubation (InSurE) and less invasive surfactant administration (LISA) are alternative replacement therapy methods for reducing the complications associated with mechanical ventilation. This study aimed to compare Classic, InSurE, LISA in Very-Low-Birth-Weight infants (VLBWIs) South Korea. Methods The Korean Neonatal Network (KNN) enrolled VLBWIs born between Ja...

Background: INSURE (Intubation, Surfactant administration, and Extubation) therapy is controversial in managing respiratory distress syndrome (RDS) late preterm newborns. This study aims to determine whether the use of infants with RDS associated improved outcomes compared similar managed CPAP alone. Methods: A retrospective cohort two different neonatal care units treatments Bucaramanga, Colom...

The Intubation-Surfactant-Extubation (INSURE) procedure is used worldwide to treat pre-term newborn infants suffering from respiratory distress syndrome, which is caused by an insufficient amount of the chemical surfactant in the lungs. With INSURE, the infant is intubated, surfactant is administered via the tube to the trachea, and at completion the infant is extubated. This improves the infan...

OBJECTIVE To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation to CPAP; CPAP/INSURE) protocol, need less mechanical ventilation than those supported with supplemental oxygen, surfactant, and mechanical ventilation if required (Oxygen/me...

As evidenced by the recent trials, a large proportion of infants can be adequately managed with CPAP, with comparable rates of BPD to those achieved in mechanically ventilated infants.2,3 These trials also made clear that a significant proportion of infants initially started on CPAP eventually require mechanical ventilation, which was more evident among infants of lower gestational age. In the ...

background: various strategies have been suggested for the treatment of respiratory distress syndrome (rds). objectives: the aim of this study was to compare the efficacies of two common methods of rds management among neonates with low birth weight. patients and methods: a cohort study was conducted on 98 neonates with definite diagnosis of rds during 2008-2009. the neonates were divided into ...

Administration of endotracheal surfactant is potentially the main treatment for neonates suffering from RDS (Respiratory Distress Syndrome), which is followed by mechanical ventilation. Late and severe complications may develop as a consequence of using mechanical ventilation. In this study, conventional methods for treatment of RDS are compared with surfactant administration, use of mechanical...