A suitable reaction system, and proper conditions were designed to produce desirable polyurethane base thickener with a calculated number average molecular weight. Initially an ethoxylated urethane prepolymer was synthesized by reaction of a polyethylene glycol (M„=6000) and dicyclohexylmethane diisocyanate using the step growth polymerization technique. Modification was carried out by reaction...

1,4-Dioxane is a stable, clear liquid at ambient temperatures and is miscible with water. It is used primarily as a solvent for chemical processing. It has also been used as a laboratory reagent; in plastic, rubber, insecticides, and herbicides; as a chemical intermediate; as part of a polymerization catalyst; and as an extraction medium of animal and vegetable oils. 1,4-Dioxane may also be fou...

A novel method to prepare 2-H-imidazolines from glyoxylic acid monohydrate and 1,2-diamines is described; the key reaction of this method is the oxidative decarboxylation of the 2-carboxy imidazolidines by NBS.

We herein report a simple and convenient one-pot synthesis of highly substituted 2-imidazolines in a regiocontrolled and stereospecific matter through the ring expansion reaction of an imidoyl chloride with an aziridine, analogous to the Heine reaction.

DABCO-catalyzed [3 + 2] annulation reaction of sulfamate-derived cyclic imines with isocyanoacetate proceeds under mild conditions, providing sulfamate-fused 2-imidazolines in moderate to excellent yields with moderate to excellent diastereoselectivities.

The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed.

Chiral nonracemic cis-4,5-bis(aryl)imidazolines have emerged as a powerful platform for the development of cancer chemotherapeutics, stimulated by the Hoffmann-La Roche discovery that Nutlin-3 can restore apoptosis in cells with wild-type p53. The lack of efficient methods for the enantioselective synthesis of cis-imidazolines, however, has limited their more general use. Our disclosure of the ...

2-Imidazolines and imidazoles have been accessed by an aza-Wittig sequence featuring novel N-acylation methodology for sulfonamides and optimized conditions for ring closure.