We describe a phenomenological model of seizure initiation, consisting of a bistable switch between stable fixed point and stable limit-cycle attractors. We determine a quasi-analytic formula for the exit time problem for our model in the presence of noise. This formula--which we equate to seizure frequency--is then validated numerically, before we extend our study to explore the combined effec...

Interactions between large marine predators and their prey are difficult to observe and little is known about the risk of predation faced by sea turtles. The frequency of predator-inflicted injuries, however, has afforded insights into the predation risk faced by many taxa. We measured the frequency of shark-inflicted injuries on green (Chelonia mydas) and loggerhead (Caretta caretta) sea turtl...

To survive, animals need to minimize exposure to damaging agents. They can either stay away from noxious stimuli (defined as avoidance), requiring the detection of remote warning cues, or run away upon exposure to noxious stimuli (defined as escape). Here we combine behavioural quantitative analyses, simulations and genetics to determine how Caenorhabditis elegans minimizes exposure to noxious ...

A specific, hitherto unpublished mechanism of escape-capture bigeminy based on rate dependent (phase 3) block of atrioventricular conduction is described. Escape-capture bigeminy is a bigeminal rhythm in which each escape beat is followed by a conducted beat. Bradley and Marriott (1958) were the first to describe this interesting electrocardiographic pattern in a case of sinoatrial block. Scham...

Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-throughput whole HIV-1 genome deep sequencing platform that combines 454 pyrosequencing with novel assembly and variant detection algorithms. In one su...

We show that nonlinear response of a quantum oscillator displays antiresonant dips and resonant peaks with varying frequency of the driving field. The effect is a consequence of special symmetry and is related to resonant multiphoton mixing of several pairs of oscillator states at a time. We also discuss escape from a metastable state of forced vibrations. Two important examples show that the p...

With its high mutation rate, HIV is capable of escape from recognition, suppression and/or killing by CD8(+) cytotoxic T lymphocytes (CTLs). The rate at which escape variants replace each other can give insights into the selective pressure imposed by single CTL clones. We investigate the effects of specific characteristics of the HIV life cycle on the dynamics of immune escape. First, it has be...