This research investigates the role of different memory components in the age-related decline of new route learning. Few studies have considered real route learning, for which the situation can be more complex, and the richness greater than with simple mazes. In this experiment, the memory of a route in a real city has been assessed considering visual scene recognition, directions recognition, ...

Episodic memory loss is a defining feature of early-stage Alzheimer's disease (AD). A test of episodic-like memory for the rat, the What-Where-Which occasion task (WWWhich), requires the association of object, location, and contextual information to form an integrated memory for an event. The WWWhich task cannot be solved by use of non-episodic information such as object familiarity and is depe...

We propose an episodic memory-based approach to the problem of pattern capture and recognition. We show how a generic episodic memory module can be enhanced with an incremental retrieval algorithm that can deal with the kind of data available for this application. We evaluate this approach on a goal schema recognition task on a complex and noisy dataset. The memory module was able to achieve th...

We report an investigation into memory for an object, its spatial location, and the context in which it appeared in rats. A novel task based on the spontaneous recognition paradigm is presented that requires memory for these three aspects. This task is performed easily by intact rats at delays of up to 1 hr. However, performance of the task is severely and selectively disrupted by transection o...

Recently we showed that the occipital cortex of congenitally blind humans is activated during verbal-memory tasks. Activation was found in regions corresponding to the retinotopic visual areas of sighted humans, including the calcarine sulcus (V1). No such occipital activation was found in sighted humans. One year later, the same blind subjects participated in a second fMRI scan, to study the c...

abstract aim and background: the present research studied episodic and semantic memory in quran memories and non- quran memories among girl students. methods and materials: research design was based on semi-experimental design. this study included 180 quran memories, beginner and non quran memories among girl students in 3 educational grades: primary, secondary and high school were chosen by cl...

Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic mild cognitive impairment (MCI), a major risk factor for the development of Alzheimer's disease (AD). In functional MRI studies with healthy participants, this same region is active during self-appraisal (requiring retrieval of semantic knowledge ab...

It is widely held that episodic retrieval can recruit two processes: a threshold context retrieval process (recollection) and a continuous signal strength process (familiarity). Conversely the processes recruited during semantic retrieval are less well specified. We developed a semantic task analogous to single-item episodic recognition to interrogate semantic recognition receiver-operating cha...

Age-related left inferior prefrontal cortex (LIPFC) blood flow reductions during semantic retrieval are associated with reduced subsequent episodic recognition memory performance but are inconsistent with age-invariant semantic retrieval performance. Therefore, we compared brain activity in young and elderly persons during low- and high-selection versions of a semantic task using ERPs recorded ...

One current challenge in cognitive training is to create a training regime that benefits multiple cognitive domains, including episodic memory, without relying on a large battery of tasks, which can be time-consuming and difficult to learn. By giving careful consideration to the neural correlates underlying episodic and working memory, we devised a computerized working memory training task in w...